<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2023 Workiva-->
<!--r:9980962c-8c03-489b-926a-266c60a03003,g:4284608e-2675-438a-ad4d-4e46a03d6c06-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/ConsolidatedStatementsofStockholdersEquity" xlink:type="simple" xlink:href="ango-20230531.xsd#ConsolidatedStatementsofStockholdersEquity"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/ConsolidatedStatementsofStockholdersEquity" xlink:type="extended" id="ib430224770794f318760ef9765dbde20_ConsolidatedStatementsofStockholdersEquity">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_228964e1-9245-4274-aff3-00802ed28309" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_24c39b68-4cf0-485b-9a16-5ea1ddc05300" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_228964e1-9245-4274-aff3-00802ed28309" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_24c39b68-4cf0-485b-9a16-5ea1ddc05300" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_8ec96d04-0c8c-47a4-8ff3-6fabd11deff4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_24c39b68-4cf0-485b-9a16-5ea1ddc05300" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_8ec96d04-0c8c-47a4-8ff3-6fabd11deff4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_9a16956f-f3b6-4fb4-9fb1-13c2da17eb62" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_24c39b68-4cf0-485b-9a16-5ea1ddc05300" xlink:to="loc_us-gaap_StockholdersEquity_9a16956f-f3b6-4fb4-9fb1-13c2da17eb62" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_bdbae424-14d7-4d97-a3e3-61f21c035052" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockCommonShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_24c39b68-4cf0-485b-9a16-5ea1ddc05300" xlink:to="loc_us-gaap_TreasuryStockCommonShares_bdbae424-14d7-4d97-a3e3-61f21c035052" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_e559d25f-d97c-4e77-888b-5e9978d3c267" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_24c39b68-4cf0-485b-9a16-5ea1ddc05300" xlink:to="loc_us-gaap_NetIncomeLoss_e559d25f-d97c-4e77-888b-5e9978d3c267" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_3984fab5-2ddf-4c23-949b-f315e3c8ec41" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_24c39b68-4cf0-485b-9a16-5ea1ddc05300" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_3984fab5-2ddf-4c23-949b-f315e3c8ec41" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_1f70e55c-46d9-4c40-ba79-c38b010a2a90" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_24c39b68-4cf0-485b-9a16-5ea1ddc05300" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_1f70e55c-46d9-4c40-ba79-c38b010a2a90" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_e8abe218-b902-4073-8c6e-66919eb3086d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_24c39b68-4cf0-485b-9a16-5ea1ddc05300" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesShareBasedCompensation_e8abe218-b902-4073-8c6e-66919eb3086d" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_993edc90-75e8-4f75-b8e7-c48c52afc3f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_24c39b68-4cf0-485b-9a16-5ea1ddc05300" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_993edc90-75e8-4f75-b8e7-c48c52afc3f0" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_f021b7a0-fdbe-47e8-a601-44524b45ebc3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_24c39b68-4cf0-485b-9a16-5ea1ddc05300" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_f021b7a0-fdbe-47e8-a601-44524b45ebc3" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_ef98cd39-ff08-44c0-8a4e-a2724b12cfdf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_24c39b68-4cf0-485b-9a16-5ea1ddc05300" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueEmployeeStockPurchasePlan_ef98cd39-ff08-44c0-8a4e-a2724b12cfdf" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_d6039f49-9e69-4010-9432-c423d4bc5f49" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_24c39b68-4cf0-485b-9a16-5ea1ddc05300" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_d6039f49-9e69-4010-9432-c423d4bc5f49" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_ccca056f-2c2f-4449-9893-962050c13836" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_24c39b68-4cf0-485b-9a16-5ea1ddc05300" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_ccca056f-2c2f-4449-9893-962050c13836" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_8ec628f1-1871-4c86-9ed5-9a66a8ab541c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_8c795dfa-027c-40b9-8f35-b4e8a0c8f2d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonShares_b25218d2-778a-4675-89bd-5f841a271159" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockCommonShares"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_25968907-cbeb-42b2-a26b-38021fcf0686" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_228964e1-9245-4274-aff3-00802ed28309" xlink:to="loc_us-gaap_StatementTable_25968907-cbeb-42b2-a26b-38021fcf0686" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_2e665b7b-2389-4abd-ad4d-aa44af5328d2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_25968907-cbeb-42b2-a26b-38021fcf0686" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_2e665b7b-2389-4abd-ad4d-aa44af5328d2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_2e665b7b-2389-4abd-ad4d-aa44af5328d2_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_2e665b7b-2389-4abd-ad4d-aa44af5328d2" xlink:to="loc_us-gaap_EquityComponentDomain_2e665b7b-2389-4abd-ad4d-aa44af5328d2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_95f940cb-35ec-493e-bd01-33e2793cdc92" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_2e665b7b-2389-4abd-ad4d-aa44af5328d2" xlink:to="loc_us-gaap_EquityComponentDomain_95f940cb-35ec-493e-bd01-33e2793cdc92" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_b8eb7353-ff5b-4107-bff4-6852c0233e74" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_95f940cb-35ec-493e-bd01-33e2793cdc92" xlink:to="loc_us-gaap_CommonStockMember_b8eb7353-ff5b-4107-bff4-6852c0233e74" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_d09919c9-189f-478f-8944-73328a057482" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_95f940cb-35ec-493e-bd01-33e2793cdc92" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_d09919c9-189f-478f-8944-73328a057482" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_12cd3cf4-f233-44b2-9e79-063a2c9c6d23" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_95f940cb-35ec-493e-bd01-33e2793cdc92" xlink:to="loc_us-gaap_RetainedEarningsMember_12cd3cf4-f233-44b2-9e79-063a2c9c6d23" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_a1dd705b-75a3-44c1-b881-0870b7f35b51" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_95f940cb-35ec-493e-bd01-33e2793cdc92" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_a1dd705b-75a3-44c1-b881-0870b7f35b51" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TreasuryStockCommonMember_d5c993fb-20cf-4b26-8220-7be84e17d021" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TreasuryStockCommonMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_95f940cb-35ec-493e-bd01-33e2793cdc92" xlink:to="loc_us-gaap_TreasuryStockCommonMember_d5c993fb-20cf-4b26-8220-7be84e17d021" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_98cd963b-a047-44b0-b608-fd44bf6d22b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_25968907-cbeb-42b2-a26b-38021fcf0686" xlink:to="loc_us-gaap_AwardTypeAxis_98cd963b-a047-44b0-b608-fd44bf6d22b9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_98cd963b-a047-44b0-b608-fd44bf6d22b9_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_98cd963b-a047-44b0-b608-fd44bf6d22b9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_98cd963b-a047-44b0-b608-fd44bf6d22b9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_368b3b49-e4d5-4f44-8ded-6a735108e41b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_98cd963b-a047-44b0-b608-fd44bf6d22b9" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_368b3b49-e4d5-4f44-8ded-6a735108e41b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_f42998d9-b0a4-4438-82e4-ebf688b7d1f4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_368b3b49-e4d5-4f44-8ded-6a735108e41b" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_f42998d9-b0a4-4438-82e4-ebf688b7d1f4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_19090691-08e0-4050-8b28-36a2107f8277" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_368b3b49-e4d5-4f44-8ded-6a735108e41b" xlink:to="loc_us-gaap_PerformanceSharesMember_19090691-08e0-4050-8b28-36a2107f8277" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/BasisofPresentationBusinessDescriptionandSummaryofSignificantAccountingPoliciesDetailsTextual" xlink:type="simple" xlink:href="ango-20230531.xsd#BasisofPresentationBusinessDescriptionandSummaryofSignificantAccountingPoliciesDetailsTextual"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/BasisofPresentationBusinessDescriptionandSummaryofSignificantAccountingPoliciesDetailsTextual" xlink:type="extended" id="i108f2b0db4004062bf8b2274540452d6_BasisofPresentationBusinessDescriptionandSummaryofSignificantAccountingPoliciesDetailsTextual">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_230e84df-6ca8-4b73-ad57-468193acee01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_ShortTermInvestmentsMaturityPeriod_cc3b6c96-06a2-4c5c-bd4e-e67a95bb107e" xlink:href="ango-20230531.xsd#ango_ShortTermInvestmentsMaturityPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_230e84df-6ca8-4b73-ad57-468193acee01" xlink:to="loc_ango_ShortTermInvestmentsMaturityPeriod_cc3b6c96-06a2-4c5c-bd4e-e67a95bb107e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_AccountsReceivableDuePeriod_f57a5c7d-6c38-4c84-a929-ed2b66ae61e5" xlink:href="ango-20230531.xsd#ango_AccountsReceivableDuePeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_230e84df-6ca8-4b73-ad57-468193acee01" xlink:to="loc_ango_AccountsReceivableDuePeriod_f57a5c7d-6c38-4c84-a929-ed2b66ae61e5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_635728eb-db29-4f86-b733-de61e2d9ce1a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_230e84df-6ca8-4b73-ad57-468193acee01" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_635728eb-db29-4f86-b733-de61e2d9ce1a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_832fddb1-6d86-4d8b-bb1b-3800fa163119" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_230e84df-6ca8-4b73-ad57-468193acee01" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_832fddb1-6d86-4d8b-bb1b-3800fa163119" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_82eb0c15-b56d-4ab1-bd95-f472332268bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_230e84df-6ca8-4b73-ad57-468193acee01" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_82eb0c15-b56d-4ab1-bd95-f472332268bb" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportingUnits_bfced91c-4516-4fd8-a723-ead33fec38a4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfReportingUnits"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_230e84df-6ca8-4b73-ad57-468193acee01" xlink:to="loc_us-gaap_NumberOfReportingUnits_bfced91c-4516-4fd8-a723-ead33fec38a4" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_89f101d8-a83c-433f-8b3d-033013337a94" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_230e84df-6ca8-4b73-ad57-468193acee01" xlink:to="loc_us-gaap_NumberOfOperatingSegments_89f101d8-a83c-433f-8b3d-033013337a94" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_69d335d7-7b80-445d-96af-56a2e8719b53" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_230e84df-6ca8-4b73-ad57-468193acee01" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_69d335d7-7b80-445d-96af-56a2e8719b53" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_2aa9f4f9-3cdf-4ef1-a246-f52d536ac281" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_69d335d7-7b80-445d-96af-56a2e8719b53" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_2aa9f4f9-3cdf-4ef1-a246-f52d536ac281" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_2aa9f4f9-3cdf-4ef1-a246-f52d536ac281_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_2aa9f4f9-3cdf-4ef1-a246-f52d536ac281" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_2aa9f4f9-3cdf-4ef1-a246-f52d536ac281_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_66d72f52-c7c0-4da6-b708-da0438570c88" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_2aa9f4f9-3cdf-4ef1-a246-f52d536ac281" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_66d72f52-c7c0-4da6-b708-da0438570c88" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BuildingAndBuildingImprovementsMember_fc242fd8-0fa5-41c9-80d4-8998440a534c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BuildingAndBuildingImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_66d72f52-c7c0-4da6-b708-da0438570c88" xlink:to="loc_us-gaap_BuildingAndBuildingImprovementsMember_fc242fd8-0fa5-41c9-80d4-8998440a534c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_3dec3fb0-4e62-4f88-8bc0-595de38b3445" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_66d72f52-c7c0-4da6-b708-da0438570c88" xlink:to="loc_us-gaap_ComputerEquipmentMember_3dec3fb0-4e62-4f88-8bc0-595de38b3445" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_9a8cd825-497f-4ed1-9c8a-8c2d45afe452" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MachineryAndEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_66d72f52-c7c0-4da6-b708-da0438570c88" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_9a8cd825-497f-4ed1-9c8a-8c2d45afe452" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_PlacementAndEvaluationUnitsMember_8732bb05-aa8b-4f28-9438-012fd3d1fa3e" xlink:href="ango-20230531.xsd#ango_PlacementAndEvaluationUnitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_66d72f52-c7c0-4da6-b708-da0438570c88" xlink:to="loc_ango_PlacementAndEvaluationUnitsMember_8732bb05-aa8b-4f28-9438-012fd3d1fa3e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_82eba331-6fcb-42b8-92d0-b29c868f5d56" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_69d335d7-7b80-445d-96af-56a2e8719b53" xlink:to="loc_srt_RangeAxis_82eba331-6fcb-42b8-92d0-b29c868f5d56" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_82eba331-6fcb-42b8-92d0-b29c868f5d56_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_82eba331-6fcb-42b8-92d0-b29c868f5d56" xlink:to="loc_srt_RangeMember_82eba331-6fcb-42b8-92d0-b29c868f5d56_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_6d10f7d3-7b7c-4982-8f79-66c17f6c3d4d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_82eba331-6fcb-42b8-92d0-b29c868f5d56" xlink:to="loc_srt_RangeMember_6d10f7d3-7b7c-4982-8f79-66c17f6c3d4d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_3f5ee6c4-0c51-4875-a99e-90c4deaab8ad" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_6d10f7d3-7b7c-4982-8f79-66c17f6c3d4d" xlink:to="loc_srt_MinimumMember_3f5ee6c4-0c51-4875-a99e-90c4deaab8ad" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_06c036a2-3279-483b-9a71-f73ee0948160" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_6d10f7d3-7b7c-4982-8f79-66c17f6c3d4d" xlink:to="loc_srt_MaximumMember_06c036a2-3279-483b-9a71-f73ee0948160" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_745a17c0-39a3-4f96-be0f-68b6eda54ba1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_69d335d7-7b80-445d-96af-56a2e8719b53" xlink:to="loc_us-gaap_AwardTypeAxis_745a17c0-39a3-4f96-be0f-68b6eda54ba1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_745a17c0-39a3-4f96-be0f-68b6eda54ba1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_745a17c0-39a3-4f96-be0f-68b6eda54ba1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_745a17c0-39a3-4f96-be0f-68b6eda54ba1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_bff58d6b-a2c7-49a3-95a7-28da6e0530bf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_745a17c0-39a3-4f96-be0f-68b6eda54ba1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_bff58d6b-a2c7-49a3-95a7-28da6e0530bf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_fa4ce534-b71e-48b7-9468-010c5be6d03a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_bff58d6b-a2c7-49a3-95a7-28da6e0530bf" xlink:to="loc_us-gaap_EmployeeStockOptionMember_fa4ce534-b71e-48b7-9468-010c5be6d03a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_0e573514-16c5-404f-9cd7-ae382c4479a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_bff58d6b-a2c7-49a3-95a7-28da6e0530bf" xlink:to="loc_us-gaap_RestrictedStockMember_0e573514-16c5-404f-9cd7-ae382c4479a5" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/AcquisitionsNarrativeDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#AcquisitionsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/AcquisitionsNarrativeDetails" xlink:type="extended" id="i0e26034a2c9549f8a7b99e3343d458d8_AcquisitionsNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_9264e58c-91ec-48db-adbf-123f78f60b38" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionConsiderationTransferred_e9414af0-017c-48e4-9e0a-ba19002ebf15" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetAcquisitionConsiderationTransferred"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_9264e58c-91ec-48db-adbf-123f78f60b38" xlink:to="loc_us-gaap_AssetAcquisitionConsiderationTransferred_e9414af0-017c-48e4-9e0a-ba19002ebf15" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiability_b577f671-dbe3-4317-a0d6-74884d5bfd66" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_9264e58c-91ec-48db-adbf-123f78f60b38" xlink:to="loc_us-gaap_ContractWithCustomerLiability_b577f671-dbe3-4317-a0d6-74884d5bfd66" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_e2f169f1-f094-4d36-9228-4117e50e79ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_9264e58c-91ec-48db-adbf-123f78f60b38" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_e2f169f1-f094-4d36-9228-4117e50e79ec" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_RevenueRemainingPerformanceObligationVariableConsiderationAmount_cc7d4080-ea50-4b51-8909-0f1ddaa9e51d" xlink:href="ango-20230531.xsd#ango_RevenueRemainingPerformanceObligationVariableConsiderationAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_9264e58c-91ec-48db-adbf-123f78f60b38" xlink:to="loc_ango_RevenueRemainingPerformanceObligationVariableConsiderationAmount_cc7d4080-ea50-4b51-8909-0f1ddaa9e51d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_AssetAcquisitionInventoryAndFixedAssets_f5496156-0bd1-4118-a29e-ea2fe07e9471" xlink:href="ango-20230531.xsd#ango_AssetAcquisitionInventoryAndFixedAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_9264e58c-91ec-48db-adbf-123f78f60b38" xlink:to="loc_ango_AssetAcquisitionInventoryAndFixedAssets_f5496156-0bd1-4118-a29e-ea2fe07e9471" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinitelivedIntangibleAssetsAcquired1_d9ae6769-0fcb-45c5-8c64-6996d49d271d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinitelivedIntangibleAssetsAcquired1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_9264e58c-91ec-48db-adbf-123f78f60b38" xlink:to="loc_us-gaap_FinitelivedIntangibleAssetsAcquired1_d9ae6769-0fcb-45c5-8c64-6996d49d271d" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsRemainingAmortizationPeriod1_4ea40c1e-d70f-45ec-b6a6-9c245fb0fa20" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsRemainingAmortizationPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_9264e58c-91ec-48db-adbf-123f78f60b38" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsRemainingAmortizationPeriod1_4ea40c1e-d70f-45ec-b6a6-9c245fb0fa20" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_dfa0feb6-1a7a-4110-b690-dd2b69cfb98a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_9264e58c-91ec-48db-adbf-123f78f60b38" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_dfa0feb6-1a7a-4110-b690-dd2b69cfb98a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_7ed37308-dac8-47bc-80e2-85f5edff6232" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_dfa0feb6-1a7a-4110-b690-dd2b69cfb98a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_7ed37308-dac8-47bc-80e2-85f5edff6232" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_7ed37308-dac8-47bc-80e2-85f5edff6232_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_7ed37308-dac8-47bc-80e2-85f5edff6232" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_7ed37308-dac8-47bc-80e2-85f5edff6232_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d41098d2-36a7-4fd5-8254-d036313d6941" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_7ed37308-dac8-47bc-80e2-85f5edff6232" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d41098d2-36a7-4fd5-8254-d036313d6941" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_f2ba11c9-bfbd-4c2c-a803-6f9bfe8626ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TechnologyBasedIntangibleAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_d41098d2-36a7-4fd5-8254-d036313d6941" xlink:to="loc_us-gaap_TechnologyBasedIntangibleAssetsMember_f2ba11c9-bfbd-4c2c-a803-6f9bfe8626ca" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionAxis_68071df0-6cce-4a6f-9182-c965e962d98f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_dfa0feb6-1a7a-4110-b690-dd2b69cfb98a" xlink:to="loc_us-gaap_AssetAcquisitionAxis_68071df0-6cce-4a6f-9182-c965e962d98f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_68071df0-6cce-4a6f-9182-c965e962d98f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AssetAcquisitionAxis_68071df0-6cce-4a6f-9182-c965e962d98f" xlink:to="loc_us-gaap_AssetAcquisitionDomain_68071df0-6cce-4a6f-9182-c965e962d98f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionDomain_51c379e9-c414-4321-ad53-ffa6308443c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetAcquisitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AssetAcquisitionAxis_68071df0-6cce-4a6f-9182-c965e962d98f" xlink:to="loc_us-gaap_AssetAcquisitionDomain_51c379e9-c414-4321-ad53-ffa6308443c5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_QXMedicalLLCCamaroSupportCatheterAssetAcquisitionMember_b9b48e2e-c31d-4792-8f14-3686366401a3" xlink:href="ango-20230531.xsd#ango_QXMedicalLLCCamaroSupportCatheterAssetAcquisitionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetAcquisitionDomain_51c379e9-c414-4321-ad53-ffa6308443c5" xlink:to="loc_ango_QXMedicalLLCCamaroSupportCatheterAssetAcquisitionMember_b9b48e2e-c31d-4792-8f14-3686366401a3" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/AssetsHeldForSaleDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#AssetsHeldForSaleDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/AssetsHeldForSaleDetails" xlink:type="extended" id="i652b9298290f4a8d8afbb6b566ec990c_AssetsHeldForSaleDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_dfcab527-a7ad-4adf-b4c0-77eaac99b418" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrentAbstract_114a2755-69af-4801-b614-3b47c32f82f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrentAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_dfcab527-a7ad-4adf-b4c0-77eaac99b418" xlink:to="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrentAbstract_114a2755-69af-4801-b614-3b47c32f82f7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationInventoryCurrent_94b8e8ee-190c-4891-a2a3-75fe1e29600c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationInventoryCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrentAbstract_114a2755-69af-4801-b614-3b47c32f82f7" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationInventoryCurrent_94b8e8ee-190c-4891-a2a3-75fe1e29600c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationPrepaidAndOtherAssetsCurrent_dd97e6c0-bc96-4f4c-97df-14360234f618" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationPrepaidAndOtherAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrentAbstract_114a2755-69af-4801-b614-3b47c32f82f7" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationPrepaidAndOtherAssetsCurrent_dd97e6c0-bc96-4f4c-97df-14360234f618" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_b3718d5e-6061-43e3-b92a-4713577dd058" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrentAbstract_114a2755-69af-4801-b614-3b47c32f82f7" xlink:to="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationCurrent_b3718d5e-6061-43e3-b92a-4713577dd058" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationNoncurrentAbstract_1fc01674-45a3-42e6-bd9c-6e36cbd68c29" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationNoncurrentAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_dfcab527-a7ad-4adf-b4c0-77eaac99b418" xlink:to="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationNoncurrentAbstract_1fc01674-45a3-42e6-bd9c-6e36cbd68c29" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipmentNoncurrent_ccff14b1-48c5-4591-8d6d-41e0d8db54b9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipmentNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationNoncurrentAbstract_1fc01674-45a3-42e6-bd9c-6e36cbd68c29" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationPropertyPlantAndEquipmentNoncurrent_ccff14b1-48c5-4591-8d6d-41e0d8db54b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationIntangibleAssetsNoncurrent_f8b54b51-f914-4c5d-ad90-033c32433a05" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationIntangibleAssetsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationNoncurrentAbstract_1fc01674-45a3-42e6-bd9c-6e36cbd68c29" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationIntangibleAssetsNoncurrent_f8b54b51-f914-4c5d-ad90-033c32433a05" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGoodwillNoncurrent_01150cdb-ed91-4338-89e9-6cde4cb9c192" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationGoodwillNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationNoncurrentAbstract_1fc01674-45a3-42e6-bd9c-6e36cbd68c29" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationGoodwillNoncurrent_01150cdb-ed91-4338-89e9-6cde4cb9c192" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent_5b734e7b-692d-4c90-a61b-ea836d12ca55" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsOfDisposalGroupIncludingDiscontinuedOperationNoncurrentAbstract_1fc01674-45a3-42e6-bd9c-6e36cbd68c29" xlink:to="loc_us-gaap_DisposalGroupIncludingDiscontinuedOperationAssetsNoncurrent_5b734e7b-692d-4c90-a61b-ea836d12ca55" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_5931d8db-e30e-4838-946c-6488207de0ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsLineItems_dfcab527-a7ad-4adf-b4c0-77eaac99b418" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_5931d8db-e30e-4838-946c-6488207de0ff" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_009e6b8e-4f0c-4fb6-8905-34d69aab927a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_5931d8db-e30e-4838-946c-6488207de0ff" xlink:to="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_009e6b8e-4f0c-4fb6-8905-34d69aab927a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_009e6b8e-4f0c-4fb6-8905-34d69aab927a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_009e6b8e-4f0c-4fb6-8905-34d69aab927a" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_009e6b8e-4f0c-4fb6-8905-34d69aab927a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_c9294a7f-d5ec-422a-a962-477811968188" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsAxis_009e6b8e-4f0c-4fb6-8905-34d69aab927a" xlink:to="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_c9294a7f-d5ec-422a-a962-477811968188" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_DialysisProductPortfolioAndBioSentryBiopsyMember_3d266dc1-d3ad-456c-9742-b769480bc876" xlink:href="ango-20230531.xsd#ango_DialysisProductPortfolioAndBioSentryBiopsyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupsIncludingDiscontinuedOperationsNameDomain_c9294a7f-d5ec-422a-a962-477811968188" xlink:to="loc_ango_DialysisProductPortfolioAndBioSentryBiopsyMember_3d266dc1-d3ad-456c-9742-b769480bc876" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationAxis_fbd96ffa-4d53-4f67-a9bd-f471d825b1e1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupClassificationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeStatementBalanceSheetAndAdditionalDisclosuresByDisposalGroupsIncludingDiscontinuedOperationsTable_5931d8db-e30e-4838-946c-6488207de0ff" xlink:to="loc_us-gaap_DisposalGroupClassificationAxis_fbd96ffa-4d53-4f67-a9bd-f471d825b1e1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_fbd96ffa-4d53-4f67-a9bd-f471d825b1e1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_fbd96ffa-4d53-4f67-a9bd-f471d825b1e1" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_fbd96ffa-4d53-4f67-a9bd-f471d825b1e1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisposalGroupClassificationDomain_15d670c3-3435-4ecc-9295-639528afa2e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisposalGroupClassificationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DisposalGroupClassificationAxis_fbd96ffa-4d53-4f67-a9bd-f471d825b1e1" xlink:to="loc_us-gaap_DisposalGroupClassificationDomain_15d670c3-3435-4ecc-9295-639528afa2e0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsHeldforsaleMember_a274b043-4812-4271-b3e0-0164ef8f3744" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DiscontinuedOperationsHeldforsaleMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisposalGroupClassificationDomain_15d670c3-3435-4ecc-9295-639528afa2e0" xlink:to="loc_us-gaap_DiscontinuedOperationsHeldforsaleMember_a274b043-4812-4271-b3e0-0164ef8f3744" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/RevenuefromContractswithCustomersDisaggregationofRevenueDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#RevenuefromContractswithCustomersDisaggregationofRevenueDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/RevenuefromContractswithCustomersDisaggregationofRevenueDetails" xlink:type="extended" id="i04dc4f6677a24a1b94556b5b227f3e5a_RevenuefromContractswithCustomersDisaggregationofRevenueDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_adbdf563-7e8c-433e-9f5e-865f3dfb254f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_85ff1b29-5c60-4e03-a1e6-9ab078bdcb75" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_adbdf563-7e8c-433e-9f5e-865f3dfb254f" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_85ff1b29-5c60-4e03-a1e6-9ab078bdcb75" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_43e5d381-d4c7-41e6-b625-e84f916497c3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_adbdf563-7e8c-433e-9f5e-865f3dfb254f" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_43e5d381-d4c7-41e6-b625-e84f916497c3" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_0dc83f8b-ab71-49b4-8abc-d782056b4299" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_43e5d381-d4c7-41e6-b625-e84f916497c3" xlink:to="loc_srt_ProductOrServiceAxis_0dc83f8b-ab71-49b4-8abc-d782056b4299" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_0dc83f8b-ab71-49b4-8abc-d782056b4299_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_0dc83f8b-ab71-49b4-8abc-d782056b4299" xlink:to="loc_srt_ProductsAndServicesDomain_0dc83f8b-ab71-49b4-8abc-d782056b4299_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_7fb43eaa-12f7-45d1-b709-e6377e6efdf3" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_0dc83f8b-ab71-49b4-8abc-d782056b4299" xlink:to="loc_srt_ProductsAndServicesDomain_7fb43eaa-12f7-45d1-b709-e6377e6efdf3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_MedTechMember_1ddf1cf2-708c-4369-9481-4dfbbaa58d10" xlink:href="ango-20230531.xsd#ango_MedTechMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_7fb43eaa-12f7-45d1-b709-e6377e6efdf3" xlink:to="loc_ango_MedTechMember_1ddf1cf2-708c-4369-9481-4dfbbaa58d10" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_MedDeviceMember_3904a9a6-1515-4ef5-a31c-01a1c81ea775" xlink:href="ango-20230531.xsd#ango_MedDeviceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_7fb43eaa-12f7-45d1-b709-e6377e6efdf3" xlink:to="loc_ango_MedDeviceMember_3904a9a6-1515-4ef5-a31c-01a1c81ea775" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_934d047f-3c40-47b9-b9c5-981cecaf2694" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_43e5d381-d4c7-41e6-b625-e84f916497c3" xlink:to="loc_srt_StatementGeographicalAxis_934d047f-3c40-47b9-b9c5-981cecaf2694" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_934d047f-3c40-47b9-b9c5-981cecaf2694_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_934d047f-3c40-47b9-b9c5-981cecaf2694" xlink:to="loc_srt_SegmentGeographicalDomain_934d047f-3c40-47b9-b9c5-981cecaf2694_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_f419af17-e9bd-48f2-a6c1-160925db5aac" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_934d047f-3c40-47b9-b9c5-981cecaf2694" xlink:to="loc_srt_SegmentGeographicalDomain_f419af17-e9bd-48f2-a6c1-160925db5aac" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_ec8ebbe1-d29f-4a29-be5c-94351f26e86f" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_f419af17-e9bd-48f2-a6c1-160925db5aac" xlink:to="loc_country_US_ec8ebbe1-d29f-4a29-be5c-94351f26e86f" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonUsMember_1db87593-72e9-4559-9c7e-a39a4cee5470" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_f419af17-e9bd-48f2-a6c1-160925db5aac" xlink:to="loc_us-gaap_NonUsMember_1db87593-72e9-4559-9c7e-a39a4cee5470" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/RevenuefromContractswithCustomersDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#RevenuefromContractswithCustomersDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/RevenuefromContractswithCustomersDetails" xlink:type="extended" id="i704a6732530746c5bfcf668313c5864d_RevenuefromContractswithCustomersDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_8f40df3e-732a-480f-8004-73998f706f1d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_RevenuePerformanceObligationPaymentTerm_e7a38870-f99e-46c3-a389-b409e92ec5d4" xlink:href="ango-20230531.xsd#ango_RevenuePerformanceObligationPaymentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_8f40df3e-732a-480f-8004-73998f706f1d" xlink:to="loc_ango_RevenuePerformanceObligationPaymentTerm_e7a38870-f99e-46c3-a389-b409e92ec5d4" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_ContractwithCustomerRightofReturnProductReturnPeriodAfterPurchaseDateRequiringPreApproval_6ad33410-f9d8-4062-9498-92f6985ffe36" xlink:href="ango-20230531.xsd#ango_ContractwithCustomerRightofReturnProductReturnPeriodAfterPurchaseDateRequiringPreApproval"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_8f40df3e-732a-480f-8004-73998f706f1d" xlink:to="loc_ango_ContractwithCustomerRightofReturnProductReturnPeriodAfterPurchaseDateRequiringPreApproval_6ad33410-f9d8-4062-9498-92f6985ffe36" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_ContractwithCustomerRightofReturnRestockingCharge_4e71b8af-1e55-4e7f-b384-6358dadf0879" xlink:href="ango-20230531.xsd#ango_ContractwithCustomerRightofReturnRestockingCharge"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_8f40df3e-732a-480f-8004-73998f706f1d" xlink:to="loc_ango_ContractwithCustomerRightofReturnRestockingCharge_4e71b8af-1e55-4e7f-b384-6358dadf0879" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_ContractwithCustomerRightofReturnMinimumRemainingProductLifePriortoReturn_f823f186-9bc0-4b20-9c4e-8ae58ba9dd89" xlink:href="ango-20230531.xsd#ango_ContractwithCustomerRightofReturnMinimumRemainingProductLifePriortoReturn"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_8f40df3e-732a-480f-8004-73998f706f1d" xlink:to="loc_ango_ContractwithCustomerRightofReturnMinimumRemainingProductLifePriortoReturn_f823f186-9bc0-4b20-9c4e-8ae58ba9dd89" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityIncreaseDecreaseForContractAcquiredInBusinessCombination_ffec5c15-15dd-47c0-bcc0-d42102b1fa4e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityIncreaseDecreaseForContractAcquiredInBusinessCombination"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_8f40df3e-732a-480f-8004-73998f706f1d" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityIncreaseDecreaseForContractAcquiredInBusinessCombination_ffec5c15-15dd-47c0-bcc0-d42102b1fa4e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_CustomerWithCustomerLiabilityRevenueRecognizedIncludingCurrentPeriod_dad89be0-2533-4ef5-832b-2a28cc7af945" xlink:href="ango-20230531.xsd#ango_CustomerWithCustomerLiabilityRevenueRecognizedIncludingCurrentPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_8f40df3e-732a-480f-8004-73998f706f1d" xlink:to="loc_ango_CustomerWithCustomerLiabilityRevenueRecognizedIncludingCurrentPeriod_dad89be0-2533-4ef5-832b-2a28cc7af945" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_c335af7c-d3a9-45ab-9865-c29393296af1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EntityWideInformationRevenueFromExternalCustomerLineItems_8f40df3e-732a-480f-8004-73998f706f1d" xlink:to="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_c335af7c-d3a9-45ab-9865-c29393296af1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_213ed350-4d2f-474b-baf7-8435509732a5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideInformationRevenueFromExternalCustomersByProductsAndServicesTable_c335af7c-d3a9-45ab-9865-c29393296af1" xlink:to="loc_srt_RangeAxis_213ed350-4d2f-474b-baf7-8435509732a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_213ed350-4d2f-474b-baf7-8435509732a5_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_213ed350-4d2f-474b-baf7-8435509732a5" xlink:to="loc_srt_RangeMember_213ed350-4d2f-474b-baf7-8435509732a5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_54fbc75a-da71-4061-93fb-3bf68f11309d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_213ed350-4d2f-474b-baf7-8435509732a5" xlink:to="loc_srt_RangeMember_54fbc75a-da71-4061-93fb-3bf68f11309d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_77000dd8-9266-4566-9b95-e05b0a714521" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_54fbc75a-da71-4061-93fb-3bf68f11309d" xlink:to="loc_srt_MinimumMember_77000dd8-9266-4566-9b95-e05b0a714521" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_7b647004-fc8a-4f51-b5da-4d5b87793a95" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_54fbc75a-da71-4061-93fb-3bf68f11309d" xlink:to="loc_srt_MaximumMember_7b647004-fc8a-4f51-b5da-4d5b87793a95" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/FairValueofFinancialInstrumentsFairValueofFinancialInstrumentsDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#FairValueofFinancialInstrumentsFairValueofFinancialInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/FairValueofFinancialInstrumentsFairValueofFinancialInstrumentsDetails" xlink:type="extended" id="i6886989014274d0699d3f36c13783b8e_FairValueofFinancialInstrumentsFairValueofFinancialInstrumentsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_74452f01-584a-420e-8ff6-94ea33cc6f25" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_58a7b516-bbd7-48ad-a863-0cb0a046f7da" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesFairValueDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_74452f01-584a-420e-8ff6-94ea33cc6f25" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_58a7b516-bbd7-48ad-a863-0cb0a046f7da" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_e09505e1-09e1-4130-82ba-0356ee0c8320" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_58a7b516-bbd7-48ad-a863-0cb0a046f7da" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_e09505e1-09e1-4130-82ba-0356ee0c8320" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_727aeaf0-63d8-4eef-8afa-57f7818e2f54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosureAbstract_58a7b516-bbd7-48ad-a863-0cb0a046f7da" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_727aeaf0-63d8-4eef-8afa-57f7818e2f54" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4de52d03-722b-463e-b65f-29a459419607" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_74452f01-584a-420e-8ff6-94ea33cc6f25" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4de52d03-722b-463e-b65f-29a459419607" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_25a00b99-b4bb-4d62-a303-dfc2e0712e9b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4de52d03-722b-463e-b65f-29a459419607" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_25a00b99-b4bb-4d62-a303-dfc2e0712e9b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_25a00b99-b4bb-4d62-a303-dfc2e0712e9b_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_25a00b99-b4bb-4d62-a303-dfc2e0712e9b" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_25a00b99-b4bb-4d62-a303-dfc2e0712e9b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_7ea6608c-989a-4ef0-a8b9-4e7e6a712866" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_25a00b99-b4bb-4d62-a303-dfc2e0712e9b" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_7ea6608c-989a-4ef0-a8b9-4e7e6a712866" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_1671004d-8b2a-49e8-b780-de87b525538e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_7ea6608c-989a-4ef0-a8b9-4e7e6a712866" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_1671004d-8b2a-49e8-b780-de87b525538e" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_055dd970-96da-4d5e-b25f-893f20fffb70" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4de52d03-722b-463e-b65f-29a459419607" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_055dd970-96da-4d5e-b25f-893f20fffb70" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_055dd970-96da-4d5e-b25f-893f20fffb70_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_055dd970-96da-4d5e-b25f-893f20fffb70" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_055dd970-96da-4d5e-b25f-893f20fffb70_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_9d59693b-a37c-407e-9894-8ef4adeed778" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_055dd970-96da-4d5e-b25f-893f20fffb70" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_9d59693b-a37c-407e-9894-8ef4adeed778" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_713d351d-62f9-4c40-a38a-ca67dbbcb199" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_9d59693b-a37c-407e-9894-8ef4adeed778" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_713d351d-62f9-4c40-a38a-ca67dbbcb199" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_2f35de42-6a35-451a-b1da-76aef1583a48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_9d59693b-a37c-407e-9894-8ef4adeed778" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_2f35de42-6a35-451a-b1da-76aef1583a48" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_96901342-da46-4d75-b53e-14aa23f56439" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_9d59693b-a37c-407e-9894-8ef4adeed778" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_96901342-da46-4d75-b53e-14aa23f56439" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/FairValueofFinancialInstrumentsFairValueofFinancialInstrumentsDetails3" xlink:type="simple" xlink:href="ango-20230531.xsd#FairValueofFinancialInstrumentsFairValueofFinancialInstrumentsDetails3"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/FairValueofFinancialInstrumentsFairValueofFinancialInstrumentsDetails3" xlink:type="extended" id="i0809a0a917a246b3b13cf28a4b8ece54_FairValueofFinancialInstrumentsFairValueofFinancialInstrumentsDetails3">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_03c65cb6-789e-49db-9d4e-0c65b2c3d5ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_FairValueLiabilitiesMeasuredOnRecurringBasisAbstract_dcada634-3c43-42a0-9273-40621d7187be" xlink:href="ango-20230531.xsd#ango_FairValueLiabilitiesMeasuredOnRecurringBasisAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_03c65cb6-789e-49db-9d4e-0c65b2c3d5ab" xlink:to="loc_ango_FairValueLiabilitiesMeasuredOnRecurringBasisAbstract_dcada634-3c43-42a0-9273-40621d7187be" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_e4e9060a-d57c-456d-ba64-71ade5661a24" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ango_FairValueLiabilitiesMeasuredOnRecurringBasisAbstract_dcada634-3c43-42a0-9273-40621d7187be" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_e4e9060a-d57c-456d-ba64-71ade5661a24" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput_a59b97eb-657f-47b6-bd89-c970ab334a6a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ango_FairValueLiabilitiesMeasuredOnRecurringBasisAbstract_dcada634-3c43-42a0-9273-40621d7187be" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput_a59b97eb-657f-47b6-bd89-c970ab334a6a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_8af8188b-48e8-40ff-a23c-0944e8d60180" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ango_FairValueLiabilitiesMeasuredOnRecurringBasisAbstract_dcada634-3c43-42a0-9273-40621d7187be" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_8af8188b-48e8-40ff-a23c-0944e8d60180" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_UndiscountedContingentConsiderationFairValueFairValueDisclosure_f8fdc57f-6286-464b-b8df-cd61a0c765d6" xlink:href="ango-20230531.xsd#ango_UndiscountedContingentConsiderationFairValueFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_03c65cb6-789e-49db-9d4e-0c65b2c3d5ab" xlink:to="loc_ango_UndiscountedContingentConsiderationFairValueFairValueDisclosure_f8fdc57f-6286-464b-b8df-cd61a0c765d6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_2948f924-6569-430c-af5d-d3430c4fde01" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_03c65cb6-789e-49db-9d4e-0c65b2c3d5ab" xlink:to="loc_us-gaap_AssetImpairmentCharges_2948f924-6569-430c-af5d-d3430c4fde01" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_9ef31838-7f55-42a2-921f-13296d05727b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_03c65cb6-789e-49db-9d4e-0c65b2c3d5ab" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_9ef31838-7f55-42a2-921f-13296d05727b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationByTypeAxis_5f03c0b5-0754-417b-8b4b-23025319dc5f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_9ef31838-7f55-42a2-921f-13296d05727b" xlink:to="loc_us-gaap_ContingentConsiderationByTypeAxis_5f03c0b5-0754-417b-8b4b-23025319dc5f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_5f03c0b5-0754-417b-8b4b-23025319dc5f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_5f03c0b5-0754-417b-8b4b-23025319dc5f" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_5f03c0b5-0754-417b-8b4b-23025319dc5f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_8969abce-17b3-4a66-82f8-2ea3d0aff6de" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_5f03c0b5-0754-417b-8b4b-23025319dc5f" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_8969abce-17b3-4a66-82f8-2ea3d0aff6de" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_RevenueBasedPaymentMember_6a020742-3b79-451c-91d6-e69997cd2432" xlink:href="ango-20230531.xsd#ango_RevenueBasedPaymentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_8969abce-17b3-4a66-82f8-2ea3d0aff6de" xlink:to="loc_ango_RevenueBasedPaymentMember_6a020742-3b79-451c-91d6-e69997cd2432" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationTechniqueAxis_bf15ed05-9570-4bb0-bd6d-ea9cdc84cef3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationTechniqueAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_9ef31838-7f55-42a2-921f-13296d05727b" xlink:to="loc_us-gaap_ValuationTechniqueAxis_bf15ed05-9570-4bb0-bd6d-ea9cdc84cef3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationTechniqueDomain_bf15ed05-9570-4bb0-bd6d-ea9cdc84cef3_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationTechniqueDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ValuationTechniqueAxis_bf15ed05-9570-4bb0-bd6d-ea9cdc84cef3" xlink:to="loc_us-gaap_ValuationTechniqueDomain_bf15ed05-9570-4bb0-bd6d-ea9cdc84cef3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationTechniqueDomain_7c67d394-9403-4094-8fa2-194636d70fbe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationTechniqueDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ValuationTechniqueAxis_bf15ed05-9570-4bb0-bd6d-ea9cdc84cef3" xlink:to="loc_us-gaap_ValuationTechniqueDomain_7c67d394-9403-4094-8fa2-194636d70fbe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationTechniqueDiscountedCashFlowMember_46ca8f0f-0b95-40c7-8dcf-315030db9233" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationTechniqueDiscountedCashFlowMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationTechniqueDomain_7c67d394-9403-4094-8fa2-194636d70fbe" xlink:to="loc_us-gaap_ValuationTechniqueDiscountedCashFlowMember_46ca8f0f-0b95-40c7-8dcf-315030db9233" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_RevenueBasedPaymentMember_a68cfcf2-26ec-49ec-9e95-4af4e719ff95" xlink:href="ango-20230531.xsd#ango_RevenueBasedPaymentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationTechniqueDomain_7c67d394-9403-4094-8fa2-194636d70fbe" xlink:to="loc_ango_RevenueBasedPaymentMember_a68cfcf2-26ec-49ec-9e95-4af4e719ff95" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_be5540c4-62bd-43c2-bba8-3b9c22858ec6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_9ef31838-7f55-42a2-921f-13296d05727b" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_be5540c4-62bd-43c2-bba8-3b9c22858ec6" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_be5540c4-62bd-43c2-bba8-3b9c22858ec6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_be5540c4-62bd-43c2-bba8-3b9c22858ec6" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_be5540c4-62bd-43c2-bba8-3b9c22858ec6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_488d605e-5fd4-4d7a-8183-909c47fa6d9a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_be5540c4-62bd-43c2-bba8-3b9c22858ec6" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_488d605e-5fd4-4d7a-8183-909c47fa6d9a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_370cc8b3-e568-40f2-a71c-28c0478d49ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_488d605e-5fd4-4d7a-8183-909c47fa6d9a" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_370cc8b3-e568-40f2-a71c-28c0478d49ae" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_15559741-1322-4750-b5e8-977fb1a1a1a5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_9ef31838-7f55-42a2-921f-13296d05727b" xlink:to="loc_srt_RangeAxis_15559741-1322-4750-b5e8-977fb1a1a1a5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_15559741-1322-4750-b5e8-977fb1a1a1a5_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_15559741-1322-4750-b5e8-977fb1a1a1a5" xlink:to="loc_srt_RangeMember_15559741-1322-4750-b5e8-977fb1a1a1a5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_9b1b3da7-ae21-46f6-a9d2-26c4b033a379" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_15559741-1322-4750-b5e8-977fb1a1a1a5" xlink:to="loc_srt_RangeMember_9b1b3da7-ae21-46f6-a9d2-26c4b033a379" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_29176cd7-98e3-4f80-936d-3637b778167b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_9b1b3da7-ae21-46f6-a9d2-26c4b033a379" xlink:to="loc_srt_MinimumMember_29176cd7-98e3-4f80-936d-3637b778167b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_774ebfa4-c4e3-4eec-8018-f4d15befcd23" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_9b1b3da7-ae21-46f6-a9d2-26c4b033a379" xlink:to="loc_srt_MaximumMember_774ebfa4-c4e3-4eec-8018-f4d15befcd23" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_bb1ba9b7-5fd1-4a47-a20f-c51d76a9c93a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_9ef31838-7f55-42a2-921f-13296d05727b" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_bb1ba9b7-5fd1-4a47-a20f-c51d76a9c93a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_bb1ba9b7-5fd1-4a47-a20f-c51d76a9c93a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_bb1ba9b7-5fd1-4a47-a20f-c51d76a9c93a" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_bb1ba9b7-5fd1-4a47-a20f-c51d76a9c93a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_84210078-ec8f-45b9-bd6c-258e40c3af97" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_bb1ba9b7-5fd1-4a47-a20f-c51d76a9c93a" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_84210078-ec8f-45b9-bd6c-258e40c3af97" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_010502a6-8112-4c1f-a655-a6d9e60a4c74" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_84210078-ec8f-45b9-bd6c-258e40c3af97" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_010502a6-8112-4c1f-a655-a6d9e60a4c74" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_9adb1d7d-49d4-4ffd-be16-2fcf0ecf5061" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_9ef31838-7f55-42a2-921f-13296d05727b" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_9adb1d7d-49d4-4ffd-be16-2fcf0ecf5061" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_9adb1d7d-49d4-4ffd-be16-2fcf0ecf5061_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_9adb1d7d-49d4-4ffd-be16-2fcf0ecf5061" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_9adb1d7d-49d4-4ffd-be16-2fcf0ecf5061_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_d114a0e3-02ee-41c2-9cd3-dbdfe716f269" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_9adb1d7d-49d4-4ffd-be16-2fcf0ecf5061" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_d114a0e3-02ee-41c2-9cd3-dbdfe716f269" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputDiscountRateMember_05655a92-321f-4a43-8693-04dc64b450a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputDiscountRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_d114a0e3-02ee-41c2-9cd3-dbdfe716f269" xlink:to="loc_us-gaap_MeasurementInputDiscountRateMember_05655a92-321f-4a43-8693-04dc64b450a8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_MeasurementInputProbabilityofPaymentMember_adbb4517-fb3f-41c0-9032-a231b00cf6cb" xlink:href="ango-20230531.xsd#ango_MeasurementInputProbabilityofPaymentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_d114a0e3-02ee-41c2-9cd3-dbdfe716f269" xlink:to="loc_ango_MeasurementInputProbabilityofPaymentMember_adbb4517-fb3f-41c0-9032-a231b00cf6cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_eb550303-05c5-4c84-8556-e522e157171d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_9ef31838-7f55-42a2-921f-13296d05727b" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_eb550303-05c5-4c84-8556-e522e157171d" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_eb550303-05c5-4c84-8556-e522e157171d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_eb550303-05c5-4c84-8556-e522e157171d" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_eb550303-05c5-4c84-8556-e522e157171d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_924d276c-3968-4b1c-b1f1-5fefabc523a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_eb550303-05c5-4c84-8556-e522e157171d" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_924d276c-3968-4b1c-b1f1-5fefabc523a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_RadiaDyneMember_1b52e4d3-591e-43a4-9217-b9ae9c7145d8" xlink:href="ango-20230531.xsd#ango_RadiaDyneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_924d276c-3968-4b1c-b1f1-5fefabc523a6" xlink:to="loc_ango_RadiaDyneMember_1b52e4d3-591e-43a4-9217-b9ae9c7145d8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_43caf2b7-1ab2-455e-b7d9-36a0d1fd26bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_9ef31838-7f55-42a2-921f-13296d05727b" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_43caf2b7-1ab2-455e-b7d9-36a0d1fd26bb" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_43caf2b7-1ab2-455e-b7d9-36a0d1fd26bb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_43caf2b7-1ab2-455e-b7d9-36a0d1fd26bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_43caf2b7-1ab2-455e-b7d9-36a0d1fd26bb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6c2a68fc-17ac-45d4-ad4f-6a9fd63a20ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_43caf2b7-1ab2-455e-b7d9-36a0d1fd26bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6c2a68fc-17ac-45d4-ad4f-6a9fd63a20ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_OarTracTrademarkMember_fed10cc6-498d-49e4-9bdf-d85b3ddd6f76" xlink:href="ango-20230531.xsd#ango_OarTracTrademarkMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_6c2a68fc-17ac-45d4-ad4f-6a9fd63a20ea" xlink:to="loc_ango_OarTracTrademarkMember_fed10cc6-498d-49e4-9bdf-d85b3ddd6f76" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/PropertyPlantandEquipmentNetDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#PropertyPlantandEquipmentNetDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/PropertyPlantandEquipmentNetDetails" xlink:type="extended" id="i08330422d2f64ddeb7cd6b2180dbf23c_PropertyPlantandEquipmentNetDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_2a5d017e-74c3-4b31-9e91-8caff7506937" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_57fee3ee-1219-46b9-80bb-e132bfb050d9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNetAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_2a5d017e-74c3-4b31-9e91-8caff7506937" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_57fee3ee-1219-46b9-80bb-e132bfb050d9" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_e20af68b-ef59-4b99-80dc-1a680544412d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_57fee3ee-1219-46b9-80bb-e132bfb050d9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_e20af68b-ef59-4b99-80dc-1a680544412d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_c3dca89d-d739-4aa1-a633-0663db7548a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_57fee3ee-1219-46b9-80bb-e132bfb050d9" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_c3dca89d-d739-4aa1-a633-0663db7548a2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_PropertyPlantAndEquipmentExcludingLandAndLandImprovements_acfcec94-5511-4626-ae46-9f53967c7135" xlink:href="ango-20230531.xsd#ango_PropertyPlantAndEquipmentExcludingLandAndLandImprovements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_57fee3ee-1219-46b9-80bb-e132bfb050d9" xlink:to="loc_ango_PropertyPlantAndEquipmentExcludingLandAndLandImprovements_acfcec94-5511-4626-ae46-9f53967c7135" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LandAndLandImprovements_a77c8e78-7633-4eb7-a4a1-f88951751191" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LandAndLandImprovements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_57fee3ee-1219-46b9-80bb-e132bfb050d9" xlink:to="loc_us-gaap_LandAndLandImprovements_a77c8e78-7633-4eb7-a4a1-f88951751191" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_1738c42f-ff86-4446-b1e4-c36e742c15c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNetAbstract_57fee3ee-1219-46b9-80bb-e132bfb050d9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_1738c42f-ff86-4446-b1e4-c36e742c15c6" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_42ab4b46-1558-49f7-8987-998b014b7a04" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Depreciation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_2a5d017e-74c3-4b31-9e91-8caff7506937" xlink:to="loc_us-gaap_Depreciation_42ab4b46-1558-49f7-8987-998b014b7a04" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_18505618-f6db-4b9c-9d70-068647161170" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_2a5d017e-74c3-4b31-9e91-8caff7506937" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_18505618-f6db-4b9c-9d70-068647161170" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_b86a9c3d-cd0e-4875-994f-0f68e10c8be6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_18505618-f6db-4b9c-9d70-068647161170" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_b86a9c3d-cd0e-4875-994f-0f68e10c8be6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b86a9c3d-cd0e-4875-994f-0f68e10c8be6_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_b86a9c3d-cd0e-4875-994f-0f68e10c8be6" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_b86a9c3d-cd0e-4875-994f-0f68e10c8be6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_3ee356a3-bffc-4ad1-9fb6-f000bb4b1906" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_b86a9c3d-cd0e-4875-994f-0f68e10c8be6" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_3ee356a3-bffc-4ad1-9fb6-f000bb4b1906" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BuildingAndBuildingImprovementsMember_c2937552-aa8e-4214-88db-4fde40735286" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BuildingAndBuildingImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_3ee356a3-bffc-4ad1-9fb6-f000bb4b1906" xlink:to="loc_us-gaap_BuildingAndBuildingImprovementsMember_c2937552-aa8e-4214-88db-4fde40735286" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_490e9164-64d7-4bb7-9aae-3ac0a8833651" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_3ee356a3-bffc-4ad1-9fb6-f000bb4b1906" xlink:to="loc_us-gaap_ComputerEquipmentMember_490e9164-64d7-4bb7-9aae-3ac0a8833651" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentMember_3dfd5b88-7194-4472-b8bd-2e76ff0b6bf6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MachineryAndEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_3ee356a3-bffc-4ad1-9fb6-f000bb4b1906" xlink:to="loc_us-gaap_MachineryAndEquipmentMember_3dfd5b88-7194-4472-b8bd-2e76ff0b6bf6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_PlacementAndEvaluationUnitsMember_48552c69-e0a2-4869-89b7-d5454befe5b8" xlink:href="ango-20230531.xsd#ango_PlacementAndEvaluationUnitsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_3ee356a3-bffc-4ad1-9fb6-f000bb4b1906" xlink:to="loc_ango_PlacementAndEvaluationUnitsMember_48552c69-e0a2-4869-89b7-d5454befe5b8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressMember_a7cdf008-77d4-4435-ac5c-46de44d02b24" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConstructionInProgressMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_3ee356a3-bffc-4ad1-9fb6-f000bb4b1906" xlink:to="loc_us-gaap_ConstructionInProgressMember_a7cdf008-77d4-4435-ac5c-46de44d02b24" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/GoodwillandIntangibleAssetsGoodwillRollforwardDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#GoodwillandIntangibleAssetsGoodwillRollforwardDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/GoodwillandIntangibleAssetsGoodwillRollforwardDetails" xlink:type="extended" id="i9275725729144b2b8717a6c4df4707b7_GoodwillandIntangibleAssetsGoodwillRollforwardDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillLineItems_f546826f-573f-40c8-9789-d7a172db0105" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillRollForward_4bbdb386-125f-4525-b163-9ca461481baa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillLineItems_f546826f-573f-40c8-9789-d7a172db0105" xlink:to="loc_us-gaap_GoodwillRollForward_4bbdb386-125f-4525-b163-9ca461481baa" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_eb9cdcdb-801d-4dae-be56-89c5456e8668" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_4bbdb386-125f-4525-b163-9ca461481baa" xlink:to="loc_us-gaap_Goodwill_eb9cdcdb-801d-4dae-be56-89c5456e8668" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_0427ccc2-14d5-4190-a16e-a4d6ac5927ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_4bbdb386-125f-4525-b163-9ca461481baa" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_0427ccc2-14d5-4190-a16e-a4d6ac5927ad" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillOtherIncreaseDecrease_62e48942-1fcd-413c-a78f-e82120e133c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillOtherIncreaseDecrease"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_4bbdb386-125f-4525-b163-9ca461481baa" xlink:to="loc_us-gaap_GoodwillOtherIncreaseDecrease_62e48942-1fcd-413c-a78f-e82120e133c4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_dccf8c46-93b8-4ba3-b00b-478799b643eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillForeignCurrencyTranslationGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_GoodwillRollForward_4bbdb386-125f-4525-b163-9ca461481baa" xlink:to="loc_us-gaap_GoodwillForeignCurrencyTranslationGainLoss_dccf8c46-93b8-4ba3-b00b-478799b643eb" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_79c28bd2-03c1-40e9-b95a-f42f512aef7e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Goodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfGoodwillTable_d6cfb8bd-4ca5-4e29-89a7-1d421a9961c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfGoodwillTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_GoodwillLineItems_f546826f-573f-40c8-9789-d7a172db0105" xlink:to="loc_us-gaap_ScheduleOfGoodwillTable_d6cfb8bd-4ca5-4e29-89a7-1d421a9961c8" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_7e1a44dd-f733-4202-b855-eb91ea73c85d" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfGoodwillTable_d6cfb8bd-4ca5-4e29-89a7-1d421a9961c8" xlink:to="loc_srt_ProductOrServiceAxis_7e1a44dd-f733-4202-b855-eb91ea73c85d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_7e1a44dd-f733-4202-b855-eb91ea73c85d_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_7e1a44dd-f733-4202-b855-eb91ea73c85d" xlink:to="loc_srt_ProductsAndServicesDomain_7e1a44dd-f733-4202-b855-eb91ea73c85d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_5a3ab044-1fc1-4654-a601-1185ad9d4626" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_7e1a44dd-f733-4202-b855-eb91ea73c85d" xlink:to="loc_srt_ProductsAndServicesDomain_5a3ab044-1fc1-4654-a601-1185ad9d4626" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_MedTechMember_ef3b2912-de8f-475f-8666-4edf3c1b6e17" xlink:href="ango-20230531.xsd#ango_MedTechMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_5a3ab044-1fc1-4654-a601-1185ad9d4626" xlink:to="loc_ango_MedTechMember_ef3b2912-de8f-475f-8666-4edf3c1b6e17" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_MedDeviceMember_448b21be-f70f-460f-abbf-30c0eddfbe2b" xlink:href="ango-20230531.xsd#ango_MedDeviceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_5a3ab044-1fc1-4654-a601-1185ad9d4626" xlink:to="loc_ango_MedDeviceMember_448b21be-f70f-460f-abbf-30c0eddfbe2b" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/GoodwillandIntangibleAssetsNarrativeDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#GoodwillandIntangibleAssetsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/GoodwillandIntangibleAssetsNarrativeDetails" xlink:type="extended" id="id56f6c0fdd7747779b7b8be57e43b37b_GoodwillandIntangibleAssetsNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_7b8dd87a-83fe-498a-a782-0fdffa55fe2c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportingUnits_ac1a9439-8646-409f-bfd2-88d07a6fe3a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfReportingUnits"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_7b8dd87a-83fe-498a-a782-0fdffa55fe2c" xlink:to="loc_us-gaap_NumberOfReportingUnits_ac1a9439-8646-409f-bfd2-88d07a6fe3a7" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_7b78c506-f7c8-4201-a325-b5ad9a4d7f83" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_7b8dd87a-83fe-498a-a782-0fdffa55fe2c" xlink:to="loc_us-gaap_NumberOfOperatingSegments_7b78c506-f7c8-4201-a325-b5ad9a4d7f83" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_e4e1c922-9e0e-438c-a22d-4f52b415fff8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_7b8dd87a-83fe-498a-a782-0fdffa55fe2c" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_e4e1c922-9e0e-438c-a22d-4f52b415fff8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_080a3f71-f316-452b-9911-c59844486ae8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_7b8dd87a-83fe-498a-a782-0fdffa55fe2c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_080a3f71-f316-452b-9911-c59844486ae8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_5fa68ea3-47fa-4a86-ae01-c1e716945ce6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_7b8dd87a-83fe-498a-a782-0fdffa55fe2c" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_5fa68ea3-47fa-4a86-ae01-c1e716945ce6" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_c4e56dbc-372b-4966-b332-cc37a0f8e4ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_7b8dd87a-83fe-498a-a782-0fdffa55fe2c" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_c4e56dbc-372b-4966-b332-cc37a0f8e4ec" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetFiniteLivedStatementOfIncomeOrComprehensiveIncomeExtensibleEnumeration_3d220553-8531-44b3-9789-9d0bf23a32d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ImpairmentOfIntangibleAssetFiniteLivedStatementOfIncomeOrComprehensiveIncomeExtensibleEnumeration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_7b8dd87a-83fe-498a-a782-0fdffa55fe2c" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetFiniteLivedStatementOfIncomeOrComprehensiveIncomeExtensibleEnumeration_3d220553-8531-44b3-9789-9d0bf23a32d1" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_d44b0593-2725-4553-9329-065fe2e05809" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_7b8dd87a-83fe-498a-a782-0fdffa55fe2c" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_d44b0593-2725-4553-9329-065fe2e05809" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_3a0b768d-593f-4d92-9f9e-f75a01f32ea6" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_d44b0593-2725-4553-9329-065fe2e05809" xlink:to="loc_srt_RangeAxis_3a0b768d-593f-4d92-9f9e-f75a01f32ea6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_3a0b768d-593f-4d92-9f9e-f75a01f32ea6_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_3a0b768d-593f-4d92-9f9e-f75a01f32ea6" xlink:to="loc_srt_RangeMember_3a0b768d-593f-4d92-9f9e-f75a01f32ea6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_645a9370-8103-4490-8eff-3dd3a4440e7b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_3a0b768d-593f-4d92-9f9e-f75a01f32ea6" xlink:to="loc_srt_RangeMember_645a9370-8103-4490-8eff-3dd3a4440e7b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_51b26b93-f000-4ab2-91d5-87fcfa152174" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_645a9370-8103-4490-8eff-3dd3a4440e7b" xlink:to="loc_srt_MinimumMember_51b26b93-f000-4ab2-91d5-87fcfa152174" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_5faa72f2-8632-4935-99c6-66723f3fcdb0" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_645a9370-8103-4490-8eff-3dd3a4440e7b" xlink:to="loc_srt_MaximumMember_5faa72f2-8632-4935-99c6-66723f3fcdb0" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/GoodwillandIntangibleAssetsIntangibleAssetsDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#GoodwillandIntangibleAssetsIntangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/GoodwillandIntangibleAssetsIntangibleAssetsDetails" xlink:type="extended" id="i22c8389fc5f84f51855fd6d430b41ef7_GoodwillandIntangibleAssetsIntangibleAssetsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_b0b46258-0975-453d-93d4-d2ed01d94250" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_5acd2eab-9730-4af0-ab56-4ef8041c3999" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_b0b46258-0975-453d-93d4-d2ed01d94250" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_5acd2eab-9730-4af0-ab56-4ef8041c3999" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_4dea449f-678f-41a8-9d87-a70ee2bb492f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_b0b46258-0975-453d-93d4-d2ed01d94250" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_4dea449f-678f-41a8-9d87-a70ee2bb492f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_773eeff7-9c95-41b9-bfd3-f4b235fd7a0b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_b0b46258-0975-453d-93d4-d2ed01d94250" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_773eeff7-9c95-41b9-bfd3-f4b235fd7a0b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable_8c896d03-30cd-4011-8a6f-a18a20cd1601" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassLineItems_b0b46258-0975-453d-93d4-d2ed01d94250" xlink:to="loc_us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable_8c896d03-30cd-4011-8a6f-a18a20cd1601" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_62c378e7-5204-4960-b5f3-dbd8805e8645" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfIndefiniteLivedIntangibleAssetsTable_8c896d03-30cd-4011-8a6f-a18a20cd1601" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_62c378e7-5204-4960-b5f3-dbd8805e8645" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_62c378e7-5204-4960-b5f3-dbd8805e8645_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_62c378e7-5204-4960-b5f3-dbd8805e8645" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_62c378e7-5204-4960-b5f3-dbd8805e8645_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8434c62f-028f-46e0-81b8-448b05e91ef1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_62c378e7-5204-4960-b5f3-dbd8805e8645" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8434c62f-028f-46e0-81b8-448b05e91ef1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_ProductTechnologiesMember_d4807603-61c7-4542-a35c-7a5edfd7fec0" xlink:href="ango-20230531.xsd#ango_ProductTechnologiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8434c62f-028f-46e0-81b8-448b05e91ef1" xlink:to="loc_ango_ProductTechnologiesMember_d4807603-61c7-4542-a35c-7a5edfd7fec0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRelationshipsMember_8205e2ed-648b-4cef-824b-a2e4891644ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CustomerRelationshipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8434c62f-028f-46e0-81b8-448b05e91ef1" xlink:to="loc_us-gaap_CustomerRelationshipsMember_8205e2ed-648b-4cef-824b-a2e4891644ff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TrademarksMember_92a2c940-8020-4512-9826-cba9506fcbd8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TrademarksMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8434c62f-028f-46e0-81b8-448b05e91ef1" xlink:to="loc_us-gaap_TrademarksMember_92a2c940-8020-4512-9826-cba9506fcbd8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicenseAgreementTermsMember_46121d83-cae4-42f4-bea1-050d20094269" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LicenseAgreementTermsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8434c62f-028f-46e0-81b8-448b05e91ef1" xlink:to="loc_us-gaap_LicenseAgreementTermsMember_46121d83-cae4-42f4-bea1-050d20094269" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#IncomeTaxesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended" id="ic8c93ee70d0a4f56bc3a95cfba8671bb_IncomeTaxesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_ango_ScheduleofIncomeTaxLineItems_ee603ea7-d48c-4d40-b409-f80e1dc4fa4f" xlink:href="ango-20230531.xsd#ango_ScheduleofIncomeTaxLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_IncomeTaxesTextualAbstract_cdf7e3fc-299e-4ed5-9ad5-a3abe41a897a" xlink:href="ango-20230531.xsd#ango_IncomeTaxesTextualAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ango_ScheduleofIncomeTaxLineItems_ee603ea7-d48c-4d40-b409-f80e1dc4fa4f" xlink:to="loc_ango_IncomeTaxesTextualAbstract_cdf7e3fc-299e-4ed5-9ad5-a3abe41a897a" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_DeferredTaxLiabilitiesPurchaseAccountingAdjustment_31890979-e39f-4eca-87cc-e3c7a999f7d7" xlink:href="ango-20230531.xsd#ango_DeferredTaxLiabilitiesPurchaseAccountingAdjustment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ango_IncomeTaxesTextualAbstract_cdf7e3fc-299e-4ed5-9ad5-a3abe41a897a" xlink:to="loc_ango_DeferredTaxLiabilitiesPurchaseAccountingAdjustment_31890979-e39f-4eca-87cc-e3c7a999f7d7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_OperatingLossCarryforwardsAmountAfterLimitationOfUse_4d69c8b3-20eb-43f0-a3e0-a8191333dcd3" xlink:href="ango-20230531.xsd#ango_OperatingLossCarryforwardsAmountAfterLimitationOfUse"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ango_IncomeTaxesTextualAbstract_cdf7e3fc-299e-4ed5-9ad5-a3abe41a897a" xlink:to="loc_ango_OperatingLossCarryforwardsAmountAfterLimitationOfUse_4d69c8b3-20eb-43f0-a3e0-a8191333dcd3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwards_406ea132-fa1e-4475-b17c-f0a58ac03737" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLossCarryforwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ango_IncomeTaxesTextualAbstract_cdf7e3fc-299e-4ed5-9ad5-a3abe41a897a" xlink:to="loc_us-gaap_OperatingLossCarryforwards_406ea132-fa1e-4475-b17c-f0a58ac03737" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillImpairmentLoss_20a220b5-e8de-498d-8ed5-354792d6b99f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GoodwillImpairmentLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ango_IncomeTaxesTextualAbstract_cdf7e3fc-299e-4ed5-9ad5-a3abe41a897a" xlink:to="loc_us-gaap_GoodwillImpairmentLoss_20a220b5-e8de-498d-8ed5-354792d6b99f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseInUnrecognizedTaxBenefitsIsReasonablyPossible_cf2d1898-1afd-42e9-af83-7d24f642722e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseInUnrecognizedTaxBenefitsIsReasonablyPossible"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ango_IncomeTaxesTextualAbstract_cdf7e3fc-299e-4ed5-9ad5-a3abe41a897a" xlink:to="loc_us-gaap_IncreaseInUnrecognizedTaxBenefitsIsReasonablyPossible_cf2d1898-1afd-42e9-af83-7d24f642722e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued_85df5f7f-488f-49a3-8633-4e7df90aec77" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_ango_IncomeTaxesTextualAbstract_cdf7e3fc-299e-4ed5-9ad5-a3abe41a897a" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsIncomeTaxPenaltiesAndInterestAccrued_85df5f7f-488f-49a3-8633-4e7df90aec77" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExaminationTable_fcf69cdd-0df8-40a0-9d25-c763a3eb6ead" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExaminationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_ango_ScheduleofIncomeTaxLineItems_ee603ea7-d48c-4d40-b409-f80e1dc4fa4f" xlink:to="loc_us-gaap_IncomeTaxExaminationTable_fcf69cdd-0df8-40a0-9d25-c763a3eb6ead" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxPeriodAxis_217f2d47-a686-41a9-b681-7def10d15c6a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TaxPeriodAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxExaminationTable_fcf69cdd-0df8-40a0-9d25-c763a3eb6ead" xlink:to="loc_us-gaap_TaxPeriodAxis_217f2d47-a686-41a9-b681-7def10d15c6a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxPeriodDomain_217f2d47-a686-41a9-b681-7def10d15c6a_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TaxPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TaxPeriodAxis_217f2d47-a686-41a9-b681-7def10d15c6a" xlink:to="loc_us-gaap_TaxPeriodDomain_217f2d47-a686-41a9-b681-7def10d15c6a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxPeriodDomain_0e93ec67-e287-4567-8e2f-6721b6e2a2be" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TaxPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TaxPeriodAxis_217f2d47-a686-41a9-b681-7def10d15c6a" xlink:to="loc_us-gaap_TaxPeriodDomain_0e93ec67-e287-4567-8e2f-6721b6e2a2be" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_TaxPeriodOneMember_c77953ab-ef69-4bc2-b79a-20a8a88a5026" xlink:href="ango-20230531.xsd#ango_TaxPeriodOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxPeriodDomain_0e93ec67-e287-4567-8e2f-6721b6e2a2be" xlink:to="loc_ango_TaxPeriodOneMember_c77953ab-ef69-4bc2-b79a-20a8a88a5026" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_TaxPeriodTwoMember_26a93470-03b1-4227-8b8b-d63821472126" xlink:href="ango-20230531.xsd#ango_TaxPeriodTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxPeriodDomain_0e93ec67-e287-4567-8e2f-6721b6e2a2be" xlink:to="loc_ango_TaxPeriodTwoMember_26a93470-03b1-4227-8b8b-d63821472126" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_TaxPeriodFourMember_97484d6a-6eb3-48fd-a39a-aa660cf35e62" xlink:href="ango-20230531.xsd#ango_TaxPeriodFourMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxPeriodDomain_0e93ec67-e287-4567-8e2f-6721b6e2a2be" xlink:to="loc_ango_TaxPeriodFourMember_97484d6a-6eb3-48fd-a39a-aa660cf35e62" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_TaxPeriodThreeMember_4a9b186e-2f73-47c2-ba11-2df4ba30b810" xlink:href="ango-20230531.xsd#ango_TaxPeriodThreeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxPeriodDomain_0e93ec67-e287-4567-8e2f-6721b6e2a2be" xlink:to="loc_ango_TaxPeriodThreeMember_4a9b186e-2f73-47c2-ba11-2df4ba30b810" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_295a5314-4d84-4b05-80c3-a83623e5e517" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxExaminationTable_fcf69cdd-0df8-40a0-9d25-c763a3eb6ead" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_295a5314-4d84-4b05-80c3-a83623e5e517" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_295a5314-4d84-4b05-80c3-a83623e5e517_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_295a5314-4d84-4b05-80c3-a83623e5e517" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_295a5314-4d84-4b05-80c3-a83623e5e517_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_9b8075a7-7a8e-4c2a-8ba8-e0f3a907e408" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_295a5314-4d84-4b05-80c3-a83623e5e517" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_9b8075a7-7a8e-4c2a-8ba8-e0f3a907e408" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DomesticCountryMember_6cf3e349-bc57-4509-b51b-811c203868fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DomesticCountryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_9b8075a7-7a8e-4c2a-8ba8-e0f3a907e408" xlink:to="loc_us-gaap_DomesticCountryMember_6cf3e349-bc57-4509-b51b-811c203868fc" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_25d3a03d-0734-4d06-a17c-13cdc4df114d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StateAndLocalJurisdictionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_9b8075a7-7a8e-4c2a-8ba8-e0f3a907e408" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_25d3a03d-0734-4d06-a17c-13cdc4df114d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IsraelTaxAuthorityMember_cb69b127-5f16-4fb9-9361-b8332ab012b1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IsraelTaxAuthorityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_9b8075a7-7a8e-4c2a-8ba8-e0f3a907e408" xlink:to="loc_us-gaap_IsraelTaxAuthorityMember_cb69b127-5f16-4fb9-9361-b8332ab012b1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_b327b751-86e8-4c53-8fd8-18e1775b4add" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_IncomeTaxExaminationTable_fcf69cdd-0df8-40a0-9d25-c763a3eb6ead" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_b327b751-86e8-4c53-8fd8-18e1775b4add" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_b327b751-86e8-4c53-8fd8-18e1775b4add_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_b327b751-86e8-4c53-8fd8-18e1775b4add" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_b327b751-86e8-4c53-8fd8-18e1775b4add_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_88ae947b-087c-4504-a4d1-ba389e9028aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_b327b751-86e8-4c53-8fd8-18e1775b4add" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_88ae947b-087c-4504-a4d1-ba389e9028aa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_EximoMedicalLtd.Member_270482af-e66e-4dff-9f8f-24eb906049df" xlink:href="ango-20230531.xsd#ango_EximoMedicalLtd.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_88ae947b-087c-4504-a4d1-ba389e9028aa" xlink:to="loc_ango_EximoMedicalLtd.Member_270482af-e66e-4dff-9f8f-24eb906049df" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/LongTermDebtNarrativeDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#LongTermDebtNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/LongTermDebtNarrativeDetails" xlink:type="extended" id="i6495d1e7276e4b5d8024d9ea819c3c28_LongTermDebtNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_27547d7f-b37b-4e31-b64f-729e4cb9ba17" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity_27547d7f-b37b-4e31-b64f-729e4cb9ba17" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_LineOfCreditFacilityMaximumBorrowingCapacityAccordianFeature_7971c2d2-873c-4fb9-bedc-d58e0c8bd539" xlink:href="ango-20230531.xsd#ango_LineOfCreditFacilityMaximumBorrowingCapacityAccordianFeature"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_ango_LineOfCreditFacilityMaximumBorrowingCapacityAccordianFeature_7971c2d2-873c-4fb9-bedc-d58e0c8bd539" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_475beef9-8665-47c1-b890-d0a630f70987" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_475beef9-8665-47c1-b890-d0a630f70987" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_DebtInstrumentDebtDefaultInterestRateIncrease_9604bb3d-2026-4fdc-846a-4c01c8ff3e8c" xlink:href="ango-20230531.xsd#ango_DebtInstrumentDebtDefaultInterestRateIncrease"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_ango_DebtInstrumentDebtDefaultInterestRateIncrease_9604bb3d-2026-4fdc-846a-4c01c8ff3e8c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_eedf546d-b72b-4e7a-a418-0d0cdc04b38f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityCommitmentFeePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_us-gaap_LineOfCreditFacilityCommitmentFeePercentage_eedf546d-b72b-4e7a-a418-0d0cdc04b38f" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_LineOfCreditFacilityNumberOfCovenants_7bb96fad-1c92-45e8-9aa1-08040464a6f9" xlink:href="ango-20230531.xsd#ango_LineOfCreditFacilityNumberOfCovenants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_ango_LineOfCreditFacilityNumberOfCovenants_7bb96fad-1c92-45e8-9aa1-08040464a6f9" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_DebtInstrumentCovenantTermsMaximumTotalLeverageRatio_9c274182-04d4-4446-b352-f4814fa2e57a" xlink:href="ango-20230531.xsd#ango_DebtInstrumentCovenantTermsMaximumTotalLeverageRatio"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_ango_DebtInstrumentCovenantTermsMaximumTotalLeverageRatio_9c274182-04d4-4446-b352-f4814fa2e57a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_DebtInstrumentCovenantTermsMaximumTotalLeverageRatioSubsequentToMaterialAcquisitions_c7794e4d-3efa-48c1-9906-d6c9713e281d" xlink:href="ango-20230531.xsd#ango_DebtInstrumentCovenantTermsMaximumTotalLeverageRatioSubsequentToMaterialAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_ango_DebtInstrumentCovenantTermsMaximumTotalLeverageRatioSubsequentToMaterialAcquisitions_c7794e4d-3efa-48c1-9906-d6c9713e281d" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_DebtInstrumentCovenantTermsMinimumFixedChargeCoverageRatio_c3873515-b31f-4e44-9cc3-14d7fb61102a" xlink:href="ango-20230531.xsd#ango_DebtInstrumentCovenantTermsMinimumFixedChargeCoverageRatio"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_ango_DebtInstrumentCovenantTermsMinimumFixedChargeCoverageRatio_c3873515-b31f-4e44-9cc3-14d7fb61102a" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_6fc051aa-401d-49b6-8ffd-9f186fea1158" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_us-gaap_LineOfCreditFacilityInterestRateAtPeriodEnd_6fc051aa-401d-49b6-8ffd-9f186fea1158" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTerm_0bcceb4d-d089-4282-9572-c0e5786d416d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTerm"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_us-gaap_DebtInstrumentTerm_0bcceb4d-d089-4282-9572-c0e5786d416d" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_8dd7fc10-76e6-4568-9a97-1f8f28916da2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfLongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfLongTermDebt_8dd7fc10-76e6-4568-9a97-1f8f28916da2" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_ec5992ce-4e1a-4a4a-abfe-4858fa418da6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_ec5992ce-4e1a-4a4a-abfe-4858fa418da6" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_DebtInstrumentFloorInterestRate_c303b64d-be40-4915-a44d-757c6673d7a5" xlink:href="ango-20230531.xsd#ango_DebtInstrumentFloorInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_ango_DebtInstrumentFloorInterestRate_c303b64d-be40-4915-a44d-757c6673d7a5" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCredit_efa712e6-a35b-43fd-ae02-389f3dec6479" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCredit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_us-gaap_LineOfCredit_efa712e6-a35b-43fd-ae02-389f3dec6479" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_71750ec5-3e8d-4eff-bed8-480b9d5fdd84" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_us-gaap_LongTermDebt_71750ec5-3e8d-4eff-bed8-480b9d5fdd84" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_fabdb0fb-cbce-4635-b527-481af827be5a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_de4e9dc3-2177-4192-866d-fb2af3e6d51e" xlink:to="loc_us-gaap_DebtInstrumentTable_fabdb0fb-cbce-4635-b527-481af827be5a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_85578d6a-a859-4e51-a849-13e05aea5b32" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_fabdb0fb-cbce-4635-b527-481af827be5a" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_85578d6a-a859-4e51-a849-13e05aea5b32" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_85578d6a-a859-4e51-a849-13e05aea5b32_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_85578d6a-a859-4e51-a849-13e05aea5b32" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_85578d6a-a859-4e51-a849-13e05aea5b32_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_42821bd2-9555-4752-bdf0-cb0ed061590d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_85578d6a-a859-4e51-a849-13e05aea5b32" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_42821bd2-9555-4752-bdf0-cb0ed061590d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_6415959f-213f-4c8d-b812-fab7ba47fd07" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_42821bd2-9555-4752-bdf0-cb0ed061590d" xlink:to="loc_us-gaap_LineOfCreditMember_6415959f-213f-4c8d-b812-fab7ba47fd07" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_f234a88e-367d-4db6-b881-bb2e21bb9a8f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_fabdb0fb-cbce-4635-b527-481af827be5a" xlink:to="loc_us-gaap_CreditFacilityAxis_f234a88e-367d-4db6-b881-bb2e21bb9a8f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_f234a88e-367d-4db6-b881-bb2e21bb9a8f_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_f234a88e-367d-4db6-b881-bb2e21bb9a8f" xlink:to="loc_us-gaap_CreditFacilityDomain_f234a88e-367d-4db6-b881-bb2e21bb9a8f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_c2940d3f-9517-4499-a9cc-19485b0bf0e7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_f234a88e-367d-4db6-b881-bb2e21bb9a8f" xlink:to="loc_us-gaap_CreditFacilityDomain_c2940d3f-9517-4499-a9cc-19485b0bf0e7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevolvingCreditFacilityMember_529ee02e-b32f-4902-bab5-9e65e36e2ba5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevolvingCreditFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_c2940d3f-9517-4499-a9cc-19485b0bf0e7" xlink:to="loc_us-gaap_RevolvingCreditFacilityMember_529ee02e-b32f-4902-bab5-9e65e36e2ba5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtMember_d78bd2d4-c89f-4b7d-865f-9630e7444b7c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_c2940d3f-9517-4499-a9cc-19485b0bf0e7" xlink:to="loc_us-gaap_SecuredDebtMember_d78bd2d4-c89f-4b7d-865f-9630e7444b7c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_2248dd82-f8a6-414b-8d88-5674b893bba9" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_fabdb0fb-cbce-4635-b527-481af827be5a" xlink:to="loc_srt_RangeAxis_2248dd82-f8a6-414b-8d88-5674b893bba9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_2248dd82-f8a6-414b-8d88-5674b893bba9_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_2248dd82-f8a6-414b-8d88-5674b893bba9" xlink:to="loc_srt_RangeMember_2248dd82-f8a6-414b-8d88-5674b893bba9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_ea1c4818-5353-443e-baad-8e8ba5b309f7" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_2248dd82-f8a6-414b-8d88-5674b893bba9" xlink:to="loc_srt_RangeMember_ea1c4818-5353-443e-baad-8e8ba5b309f7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_e6812cc5-7a65-40c5-8672-4d424bba6d0c" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_ea1c4818-5353-443e-baad-8e8ba5b309f7" xlink:to="loc_srt_MinimumMember_e6812cc5-7a65-40c5-8672-4d424bba6d0c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_0ca540d9-1be4-40cd-b8bd-e64a96c1b9d9" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_ea1c4818-5353-443e-baad-8e8ba5b309f7" xlink:to="loc_srt_MaximumMember_0ca540d9-1be4-40cd-b8bd-e64a96c1b9d9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_6c31a571-6253-4403-aa36-e8d963c19d3d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_fabdb0fb-cbce-4635-b527-481af827be5a" xlink:to="loc_us-gaap_VariableRateAxis_6c31a571-6253-4403-aa36-e8d963c19d3d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_6c31a571-6253-4403-aa36-e8d963c19d3d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableRateAxis_6c31a571-6253-4403-aa36-e8d963c19d3d" xlink:to="loc_us-gaap_VariableRateDomain_6c31a571-6253-4403-aa36-e8d963c19d3d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_d37faed8-646b-4a11-be65-7b9ae62590a9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableRateAxis_6c31a571-6253-4403-aa36-e8d963c19d3d" xlink:to="loc_us-gaap_VariableRateDomain_d37faed8-646b-4a11-be65-7b9ae62590a9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BaseRateMember_0b2a1aae-21f8-4ec2-b823-16f9f5f2fe5b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BaseRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_d37faed8-646b-4a11-be65-7b9ae62590a9" xlink:to="loc_us-gaap_BaseRateMember_0b2a1aae-21f8-4ec2-b823-16f9f5f2fe5b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredOvernightFinancingRateSofrOvernightIndexSwapRateMember_78e8524d-8b30-442e-832a-ba9a0450476c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SecuredOvernightFinancingRateSofrOvernightIndexSwapRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableRateDomain_d37faed8-646b-4a11-be65-7b9ae62590a9" xlink:to="loc_us-gaap_SecuredOvernightFinancingRateSofrOvernightIndexSwapRateMember_78e8524d-8b30-442e-832a-ba9a0450476c" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/LongTermDebtLongTermDebtScheduleDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#LongTermDebtLongTermDebtScheduleDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/LongTermDebtLongTermDebtScheduleDetails" xlink:type="extended" id="ie06e0e2a9f0f4b61891da098e79b6797_LongTermDebtLongTermDebtScheduleDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_a998ed0f-3c22-4d8e-86ce-c6645fc75047" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_0d9bfe3d-17d9-45fb-88ce-f8ed85c2a617" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a998ed0f-3c22-4d8e-86ce-c6645fc75047" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_0d9bfe3d-17d9-45fb-88ce-f8ed85c2a617" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_8647d651-87fe-4590-970a-cb091465c4ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a998ed0f-3c22-4d8e-86ce-c6645fc75047" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_8647d651-87fe-4590-970a-cb091465c4ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_b80fc91d-8df6-424d-9f44-374067b75cff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a998ed0f-3c22-4d8e-86ce-c6645fc75047" xlink:to="loc_us-gaap_LongTermDebt_b80fc91d-8df6-424d-9f44-374067b75cff" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_0498a261-e282-41cb-bddf-37311185e1c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a998ed0f-3c22-4d8e-86ce-c6645fc75047" xlink:to="loc_us-gaap_DebtInstrumentTable_0498a261-e282-41cb-bddf-37311185e1c2" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_142f80c3-4ecb-4dd0-9322-ab9763891665" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_0498a261-e282-41cb-bddf-37311185e1c2" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_142f80c3-4ecb-4dd0-9322-ab9763891665" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_142f80c3-4ecb-4dd0-9322-ab9763891665_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_142f80c3-4ecb-4dd0-9322-ab9763891665" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_142f80c3-4ecb-4dd0-9322-ab9763891665_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_667e9df8-b9b7-40c4-937d-f55d05a76da2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_142f80c3-4ecb-4dd0-9322-ab9763891665" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_667e9df8-b9b7-40c4-937d-f55d05a76da2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditMember_3490d48a-7ccc-489a-a960-2c10e0669685" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_667e9df8-b9b7-40c4-937d-f55d05a76da2" xlink:to="loc_us-gaap_LineOfCreditMember_3490d48a-7ccc-489a-a960-2c10e0669685" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LoansPayableMember_15e071ff-46f4-48c9-85d5-aae5fdec33d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LoansPayableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_667e9df8-b9b7-40c4-937d-f55d05a76da2" xlink:to="loc_us-gaap_LoansPayableMember_15e071ff-46f4-48c9-85d5-aae5fdec33d8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_6379ad83-0f1f-4470-9fe5-3da259429161" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_0498a261-e282-41cb-bddf-37311185e1c2" xlink:to="loc_us-gaap_DebtInstrumentAxis_6379ad83-0f1f-4470-9fe5-3da259429161" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_6379ad83-0f1f-4470-9fe5-3da259429161_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_6379ad83-0f1f-4470-9fe5-3da259429161" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_6379ad83-0f1f-4470-9fe5-3da259429161_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_fad38654-2784-42fa-ada2-5392fe2fe47e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_6379ad83-0f1f-4470-9fe5-3da259429161" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_fad38654-2784-42fa-ada2-5392fe2fe47e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_RevolvingFacilityMember_02b2133b-5e06-4ea3-90cd-82fa96e9e6b2" xlink:href="ango-20230531.xsd#ango_RevolvingFacilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_fad38654-2784-42fa-ada2-5392fe2fe47e" xlink:to="loc_ango_RevolvingFacilityMember_02b2133b-5e06-4ea3-90cd-82fa96e9e6b2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityAxis_f266aefc-519a-44a3-8cec-6c3bf0e04312" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_0498a261-e282-41cb-bddf-37311185e1c2" xlink:to="loc_us-gaap_CreditFacilityAxis_f266aefc-519a-44a3-8cec-6c3bf0e04312" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_f266aefc-519a-44a3-8cec-6c3bf0e04312_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_CreditFacilityAxis_f266aefc-519a-44a3-8cec-6c3bf0e04312" xlink:to="loc_us-gaap_CreditFacilityDomain_f266aefc-519a-44a3-8cec-6c3bf0e04312_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditFacilityDomain_2a01fd18-165f-4974-99ac-39f5d329038c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditFacilityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_CreditFacilityAxis_f266aefc-519a-44a3-8cec-6c3bf0e04312" xlink:to="loc_us-gaap_CreditFacilityDomain_2a01fd18-165f-4974-99ac-39f5d329038c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredDebtMember_ae725ba4-0700-462f-b480-27292b7ddbf1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SecuredDebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CreditFacilityDomain_2a01fd18-165f-4974-99ac-39f5d329038c" xlink:to="loc_us-gaap_SecuredDebtMember_ae725ba4-0700-462f-b480-27292b7ddbf1" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/StockholdersEquityNarrativeDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#StockholdersEquityNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/StockholdersEquityNarrativeDetails" xlink:type="extended" id="i3ef88e5d3b5140c49ee1c05484b8049a_StockholdersEquityNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherOwnershipInterestsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_CapitalStockSharesAuthorized_bca13f8e-45f8-4bce-b4d5-86320e39a471" xlink:href="ango-20230531.xsd#ango_CapitalStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_ango_CapitalStockSharesAuthorized_bca13f8e-45f8-4bce-b4d5-86320e39a471" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_e58cfd34-a7d6-4b69-a5b4-b84a6019b2a7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_e58cfd34-a7d6-4b69-a5b4-b84a6019b2a7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_ecb2710e-7f0f-400d-8e36-81b4df70f6fe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_ecb2710e-7f0f-400d-8e36-81b4df70f6fe" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_4d81e0e5-a9dd-4ef7-974f-4f1b5c318e3d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_4d81e0e5-a9dd-4ef7-974f-4f1b5c318e3d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_dfb662bc-00eb-4443-b1d1-985af3d6ea1c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_dfb662bc-00eb-4443-b1d1-985af3d6ea1c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_CommonStockVotesPerShare_3c996854-a004-4c17-be16-93cc1eeeb2f8" xlink:href="ango-20230531.xsd#ango_CommonStockVotesPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_ango_CommonStockVotesPerShare_3c996854-a004-4c17-be16-93cc1eeeb2f8" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_28966329-efb2-40a3-9a00-742da21e0914" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_28966329-efb2-40a3-9a00-742da21e0914" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardGrantedToEmployeesVestingPercentage_734613d6-0bbb-444b-878f-6ebde62078f5" xlink:href="ango-20230531.xsd#ango_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardGrantedToEmployeesVestingPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_ango_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardGrantedToEmployeesVestingPercentage_734613d6-0bbb-444b-878f-6ebde62078f5" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardGrantedToEmployeesVestingPeriod1_196334b2-d98b-44fe-8b7f-a9a7614e90f9" xlink:href="ango-20230531.xsd#ango_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardGrantedToEmployeesVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_ango_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardGrantedToEmployeesVestingPeriod1_196334b2-d98b-44fe-8b7f-a9a7614e90f9" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_84784755-8589-4d34-9b60-3aa921ef842e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_84784755-8589-4d34-9b60-3aa921ef842e" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_fbb3b9cd-732e-4e34-9cf3-b8712805903e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_fbb3b9cd-732e-4e34-9cf3-b8712805903e" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_8455130b-06a6-4403-953e-4bf5582f8a2a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_8455130b-06a6-4403-953e-4bf5582f8a2a" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_0db727c2-072c-4da5-8487-4635f68aa488" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_0db727c2-072c-4da5-8487-4635f68aa488" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_1bfb4aa4-2aa9-4f5b-8584-d7034b9330b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_1bfb4aa4-2aa9-4f5b-8584-d7034b9330b2" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_cf377705-e849-456b-b1f5-aea5d6cad641" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_cf377705-e849-456b-b1f5-aea5d6cad641" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_a83ed4e7-aa14-4f6f-9c65-cc4af158144a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_a83ed4e7-aa14-4f6f-9c65-cc4af158144a" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_07b16c38-7ee1-4231-9c57-7ce6abe415c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationTaxBenefitFromCompensationExpense_07b16c38-7ee1-4231-9c57-7ce6abe415c8" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_352148d9-a358-4b3a-abf6-37423a0eab84" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_352148d9-a358-4b3a-abf6-37423a0eab84" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_69b847d3-76b1-4d29-b0ba-3435b3784a2b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_69b847d3-76b1-4d29-b0ba-3435b3784a2b" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue_f93d3229-e27a-450a-a339-0d5e52308b6a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodTotalFairValue_f93d3229-e27a-450a-a339-0d5e52308b6a" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_572cd612-5eb4-4424-9eed-72d43160327f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized_572cd612-5eb4-4424-9eed-72d43160327f" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_5f88b0f5-b05a-421e-bc16-2411f679d273" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_5f88b0f5-b05a-421e-bc16-2411f679d273" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsCompensationCostProbableRecognitionPerformancePeriod_798f609e-fb1b-4c54-a5e3-803bee87a291" xlink:href="ango-20230531.xsd#ango_SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsCompensationCostProbableRecognitionPerformancePeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_ango_SharebasedCompensationArrangementbySharebasedPaymentAwardEquityInstrumentsOtherthanOptionsCompensationCostProbableRecognitionPerformancePeriod_798f609e-fb1b-4c54-a5e3-803bee87a291" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_38146c48-e021-4d85-a7f3-2d57c43818ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_38146c48-e021-4d85-a7f3-2d57c43818ad" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_730b9af3-d8ed-4761-86bc-fd4e9d4f12d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAuthorized_730b9af3-d8ed-4761-86bc-fd4e9d4f12d5" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_NumberOfSharePurchasePeriod_9ea256d9-9a8a-4910-be23-0f6862214da9" xlink:href="ango-20230531.xsd#ango_NumberOfSharePurchasePeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_ango_NumberOfSharePurchasePeriod_9ea256d9-9a8a-4910-be23-0f6862214da9" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_SharePurchasePeriod_8c7a1b65-0676-40c0-9b68-2b4644221f91" xlink:href="ango-20230531.xsd#ango_SharePurchasePeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_ango_SharePurchasePeriod_8c7a1b65-0676-40c0-9b68-2b4644221f91" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_EmployeePlanParticipatingEligibilityPeriod_bd62463b-a44a-4a8b-b21b-f2db9102bb6c" xlink:href="ango-20230531.xsd#ango_EmployeePlanParticipatingEligibilityPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_ango_EmployeePlanParticipatingEligibilityPeriod_bd62463b-a44a-4a8b-b21b-f2db9102bb6c" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_SharebasedCompensationArrangementbySharebasedPaymentAwardWorkingHoursPerWeektobeEligible_1db370ab-8960-49be-8ae2-455d1a8bd2a3" xlink:href="ango-20230531.xsd#ango_SharebasedCompensationArrangementbySharebasedPaymentAwardWorkingHoursPerWeektobeEligible"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_ango_SharebasedCompensationArrangementbySharebasedPaymentAwardWorkingHoursPerWeektobeEligible_1db370ab-8960-49be-8ae2-455d1a8bd2a3" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_SharebasedCompensationArrangementbySharebasedPaymentAwardWorkingMonthsPerYeartobeEligible_0204540c-cb41-414d-bec1-46179519f7dd" xlink:href="ango-20230531.xsd#ango_SharebasedCompensationArrangementbySharebasedPaymentAwardWorkingMonthsPerYeartobeEligible"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_ango_SharebasedCompensationArrangementbySharebasedPaymentAwardWorkingMonthsPerYeartobeEligible_0204540c-cb41-414d-bec1-46179519f7dd" xlink:type="arc" order="29"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_EmployeePlanParticipatingEligibilityThresholdPercentage_ebe88cec-ba04-44bf-8714-37b069268d70" xlink:href="ango-20230531.xsd#ango_EmployeePlanParticipatingEligibilityThresholdPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_ango_EmployeePlanParticipatingEligibilityThresholdPercentage_ebe88cec-ba04-44bf-8714-37b069268d70" xlink:type="arc" order="30"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercentOnFirstDayOfOfferingPeriod_50a2a664-64fa-4374-bf14-b78e92fab3b8" xlink:href="ango-20230531.xsd#ango_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercentOnFirstDayOfOfferingPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_ango_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercentOnFirstDayOfOfferingPeriod_50a2a664-64fa-4374-bf14-b78e92fab3b8" xlink:type="arc" order="31"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_4ab5fc89-20d5-438a-84df-e48de2e15825" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_4ab5fc89-20d5-438a-84df-e48de2e15825" xlink:type="arc" order="32"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_516ca3e8-a5ae-4263-a727-6784b78eb63e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_516ca3e8-a5ae-4263-a727-6784b78eb63e" xlink:type="arc" order="33"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_6c39cc56-e9c3-4526-aa5b-a96814b75539" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_6c39cc56-e9c3-4526-aa5b-a96814b75539" xlink:type="arc" order="34"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPerShareWeightedAveragePriceOfSharesPurchased_23e1ebc3-73cf-48fa-ac03-ebd9259ec542" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPerShareWeightedAveragePriceOfSharesPurchased"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardPerShareWeightedAveragePriceOfSharesPurchased_23e1ebc3-73cf-48fa-ac03-ebd9259ec542" xlink:type="arc" order="35"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_d5cb9dac-ce33-45be-a93e-28cff0740ee5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_d5cb9dac-ce33-45be-a93e-28cff0740ee5" xlink:type="arc" order="36"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_bc70f301-ae4f-4dd2-85eb-f8583a6ee2b6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardRequisiteServicePeriod1_bc70f301-ae4f-4dd2-85eb-f8583a6ee2b6" xlink:type="arc" order="37"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingPeriodIncreaseDecrease_ebd9e0fd-d5a2-4db4-a54e-244827e81ba6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingPeriodIncreaseDecrease"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingPeriodIncreaseDecrease_ebd9e0fd-d5a2-4db4-a54e-244827e81ba6" xlink:type="arc" order="38"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfOtherOwnershipInterestsTable_6efcc407-3eb7-4346-a3cd-f4ac35e91508" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfOtherOwnershipInterestsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OtherOwnershipInterestsLineItems_d146b5e8-b0f9-41a3-bf76-6e1a7d2be12c" xlink:to="loc_us-gaap_ScheduleOfOtherOwnershipInterestsTable_6efcc407-3eb7-4346-a3cd-f4ac35e91508" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_fdca4444-39ab-4de5-b244-484981fdd7eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfOtherOwnershipInterestsTable_6efcc407-3eb7-4346-a3cd-f4ac35e91508" xlink:to="loc_us-gaap_PlanNameAxis_fdca4444-39ab-4de5-b244-484981fdd7eb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_fdca4444-39ab-4de5-b244-484981fdd7eb_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_fdca4444-39ab-4de5-b244-484981fdd7eb" xlink:to="loc_us-gaap_PlanNameDomain_fdca4444-39ab-4de5-b244-484981fdd7eb_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_4e20cfbc-b61e-43c9-88fb-9cd362d17b48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_fdca4444-39ab-4de5-b244-484981fdd7eb" xlink:to="loc_us-gaap_PlanNameDomain_4e20cfbc-b61e-43c9-88fb-9cd362d17b48" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_TwoThousandAndFourStockAndIncentiveAwardPlanMember_c58d5b86-22bb-41ba-a592-5369bfd66392" xlink:href="ango-20230531.xsd#ango_TwoThousandAndFourStockAndIncentiveAwardPlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_4e20cfbc-b61e-43c9-88fb-9cd362d17b48" xlink:to="loc_ango_TwoThousandAndFourStockAndIncentiveAwardPlanMember_c58d5b86-22bb-41ba-a592-5369bfd66392" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_StockPurchasePlanMember_18ec1062-5e55-4fbd-bb5f-9c4117401b1f" xlink:href="ango-20230531.xsd#ango_StockPurchasePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_4e20cfbc-b61e-43c9-88fb-9cd362d17b48" xlink:to="loc_ango_StockPurchasePlanMember_18ec1062-5e55-4fbd-bb5f-9c4117401b1f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_StockAndIncentiveAwardPlan2020Member_e9a393cb-d34f-4f85-84a3-f5cbc7ea1208" xlink:href="ango-20230531.xsd#ango_StockAndIncentiveAwardPlan2020Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_4e20cfbc-b61e-43c9-88fb-9cd362d17b48" xlink:to="loc_ango_StockAndIncentiveAwardPlan2020Member_e9a393cb-d34f-4f85-84a3-f5cbc7ea1208" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_EmployeeStockPurchasePlanMember_11c10f6d-3765-4350-897c-2a55940c20ac" xlink:href="ango-20230531.xsd#ango_EmployeeStockPurchasePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_4e20cfbc-b61e-43c9-88fb-9cd362d17b48" xlink:to="loc_ango_EmployeeStockPurchasePlanMember_11c10f6d-3765-4350-897c-2a55940c20ac" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityEquityAxis_ed2503d0-4d61-409b-bc01-00713d4cc0a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OptionIndexedToIssuersEquityEquityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfOtherOwnershipInterestsTable_6efcc407-3eb7-4346-a3cd-f4ac35e91508" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityEquityAxis_ed2503d0-4d61-409b-bc01-00713d4cc0a5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_ed2503d0-4d61-409b-bc01-00713d4cc0a5_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityEquityAxis_ed2503d0-4d61-409b-bc01-00713d4cc0a5" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_ed2503d0-4d61-409b-bc01-00713d4cc0a5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_4c7297d3-0365-40c1-931d-6e487ab4f27b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OptionIndexedToIssuersEquityTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityEquityAxis_ed2503d0-4d61-409b-bc01-00713d4cc0a5" xlink:to="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_4c7297d3-0365-40c1-931d-6e487ab4f27b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_2043236a-ce03-4758-9eee-b5ee6e8d61a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OptionIndexedToIssuersEquityTypeDomain_4c7297d3-0365-40c1-931d-6e487ab4f27b" xlink:to="loc_us-gaap_EmployeeStockOptionMember_2043236a-ce03-4758-9eee-b5ee6e8d61a8" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_7662577c-38fd-40f6-982d-bfbc3961d89d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfOtherOwnershipInterestsTable_6efcc407-3eb7-4346-a3cd-f4ac35e91508" xlink:to="loc_us-gaap_AwardTypeAxis_7662577c-38fd-40f6-982d-bfbc3961d89d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7662577c-38fd-40f6-982d-bfbc3961d89d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_7662577c-38fd-40f6-982d-bfbc3961d89d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_7662577c-38fd-40f6-982d-bfbc3961d89d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2ff94a68-3880-4291-a7f2-0a9131b39f5b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_7662577c-38fd-40f6-982d-bfbc3961d89d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2ff94a68-3880-4291-a7f2-0a9131b39f5b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_3a0a0079-017a-43e5-82c6-43740a29b7e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2ff94a68-3880-4291-a7f2-0a9131b39f5b" xlink:to="loc_us-gaap_EmployeeStockOptionMember_3a0a0079-017a-43e5-82c6-43740a29b7e0" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_b09c2f3e-1a0c-4a5f-99e8-6f6c8148f9c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2ff94a68-3880-4291-a7f2-0a9131b39f5b" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_b09c2f3e-1a0c-4a5f-99e8-6f6c8148f9c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_PerformanceShareAndRestrictedStockUnitAwardsMember_2ddde8b4-b199-4019-be8b-a4da3253b422" xlink:href="ango-20230531.xsd#ango_PerformanceShareAndRestrictedStockUnitAwardsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2ff94a68-3880-4291-a7f2-0a9131b39f5b" xlink:to="loc_ango_PerformanceShareAndRestrictedStockUnitAwardsMember_2ddde8b4-b199-4019-be8b-a4da3253b422" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_PerformanceSharesIncludingThreeYearMarketConditionMember_a2da4378-d9ba-42e5-b689-55c4948d73d8" xlink:href="ango-20230531.xsd#ango_PerformanceSharesIncludingThreeYearMarketConditionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_2ff94a68-3880-4291-a7f2-0a9131b39f5b" xlink:to="loc_ango_PerformanceSharesIncludingThreeYearMarketConditionMember_a2da4378-d9ba-42e5-b689-55c4948d73d8" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/StockholdersEquityDetails2" xlink:type="simple" xlink:href="ango-20230531.xsd#StockholdersEquityDetails2"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/StockholdersEquityDetails2" xlink:type="extended" id="i5e8c2fe6dce34ef6acab95bf8da34beb_StockholdersEquityDetails2">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f5fb4507-6f4c-4f8c-8f89-bc5139f502cb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_9c35e7af-bf38-4684-a8b0-3a3f182f5fb2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f5fb4507-6f4c-4f8c-8f89-bc5139f502cb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_9c35e7af-bf38-4684-a8b0-3a3f182f5fb2" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_1aff90d7-3903-47d9-bf03-383d410bcfc3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_9c35e7af-bf38-4684-a8b0-3a3f182f5fb2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_1aff90d7-3903-47d9-bf03-383d410bcfc3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_1f042967-f1b3-4c27-aa44-ce033f39e58f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_9c35e7af-bf38-4684-a8b0-3a3f182f5fb2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_1f042967-f1b3-4c27-aa44-ce033f39e58f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_83e3c342-0851-4ca2-8de0-6341173d3fb0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_9c35e7af-bf38-4684-a8b0-3a3f182f5fb2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_83e3c342-0851-4ca2-8de0-6341173d3fb0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_32854ca6-a83a-4734-a93e-668de265b5ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_9c35e7af-bf38-4684-a8b0-3a3f182f5fb2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_32854ca6-a83a-4734-a93e-668de265b5ca" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_f95c607f-d156-4bdb-b036-8bbcf0531245" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_67f62d09-a815-40c3-9ae1-28895d4822e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f5fb4507-6f4c-4f8c-8f89-bc5139f502cb" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_67f62d09-a815-40c3-9ae1-28895d4822e2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_6df28d28-3762-4afc-8617-2a0873bedea3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_67f62d09-a815-40c3-9ae1-28895d4822e2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_6df28d28-3762-4afc-8617-2a0873bedea3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_52587297-59ab-4c42-9b4b-6c4946c24c48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_67f62d09-a815-40c3-9ae1-28895d4822e2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_52587297-59ab-4c42-9b4b-6c4946c24c48" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_798aff5d-9c98-48fa-973f-80d51cfe368a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_67f62d09-a815-40c3-9ae1-28895d4822e2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_798aff5d-9c98-48fa-973f-80d51cfe368a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_0fa2d1ea-79bb-4415-acf4-6fa4f6fe765b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_67f62d09-a815-40c3-9ae1-28895d4822e2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_0fa2d1ea-79bb-4415-acf4-6fa4f6fe765b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_fb2f933c-a834-4399-bd30-b8e2ef132901" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_b9ba6a24-3a90-403e-9e71-2e1c9e8fe833" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_f5fb4507-6f4c-4f8c-8f89-bc5139f502cb" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_b9ba6a24-3a90-403e-9e71-2e1c9e8fe833" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_b038d0ee-db44-452c-a34b-c27168c5c4b1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_b9ba6a24-3a90-403e-9e71-2e1c9e8fe833" xlink:to="loc_us-gaap_AwardTypeAxis_b038d0ee-db44-452c-a34b-c27168c5c4b1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b038d0ee-db44-452c-a34b-c27168c5c4b1_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_b038d0ee-db44-452c-a34b-c27168c5c4b1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b038d0ee-db44-452c-a34b-c27168c5c4b1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a0600b6d-a154-4d0e-b44e-e501baf356a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_b038d0ee-db44-452c-a34b-c27168c5c4b1" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a0600b6d-a154-4d0e-b44e-e501baf356a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockUnitsRSUMember_5188e95e-3749-47a7-964e-3270bb7c3a21" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedStockUnitsRSUMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a0600b6d-a154-4d0e-b44e-e501baf356a6" xlink:to="loc_us-gaap_RestrictedStockUnitsRSUMember_5188e95e-3749-47a7-964e-3270bb7c3a21" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PerformanceSharesMember_d934b143-5568-4a0d-94aa-e7d27a0a5996" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PerformanceSharesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_a0600b6d-a154-4d0e-b44e-e501baf356a6" xlink:to="loc_us-gaap_PerformanceSharesMember_d934b143-5568-4a0d-94aa-e7d27a0a5996" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/StockholdersEquityCompensationExpenseDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#StockholdersEquityCompensationExpenseDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/StockholdersEquityCompensationExpenseDetails" xlink:type="extended" id="i85e33c66619241bbae7765648c65218d_StockholdersEquityCompensationExpenseDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_b50d8538-7b96-41e4-8adb-2d1785875f9d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_b2748b55-c885-4077-9a28-5de84b88bf3c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_b50d8538-7b96-41e4-8adb-2d1785875f9d" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_b2748b55-c885-4077-9a28-5de84b88bf3c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_67409461-ec9b-46ac-a56f-c8ac857198d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_b50d8538-7b96-41e4-8adb-2d1785875f9d" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_67409461-ec9b-46ac-a56f-c8ac857198d4" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_a98b8e55-96c7-40c0-907f-f4b0c851aded" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_67409461-ec9b-46ac-a56f-c8ac857198d4" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_a98b8e55-96c7-40c0-907f-f4b0c851aded" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_a98b8e55-96c7-40c0-907f-f4b0c851aded_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_a98b8e55-96c7-40c0-907f-f4b0c851aded" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_a98b8e55-96c7-40c0-907f-f4b0c851aded_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_25206aa2-98fc-4693-a89a-f4a8def612cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_a98b8e55-96c7-40c0-907f-f4b0c851aded" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_25206aa2-98fc-4693-a89a-f4a8def612cc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_9a8effd3-d239-4950-985b-1a39595466ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfSalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_25206aa2-98fc-4693-a89a-f4a8def612cc" xlink:to="loc_us-gaap_CostOfSalesMember_9a8effd3-d239-4950-985b-1a39595466ed" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_ResearchAndDevelopmentMember_22d5c047-db52-4a2d-bfb2-9f417d14be23" xlink:href="ango-20230531.xsd#ango_ResearchAndDevelopmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_25206aa2-98fc-4693-a89a-f4a8def612cc" xlink:to="loc_ango_ResearchAndDevelopmentMember_22d5c047-db52-4a2d-bfb2-9f417d14be23" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_SalesandMarketingMember_9562be16-c39e-42da-a432-29c3e63bc509" xlink:href="ango-20230531.xsd#ango_SalesandMarketingMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_25206aa2-98fc-4693-a89a-f4a8def612cc" xlink:to="loc_ango_SalesandMarketingMember_9562be16-c39e-42da-a432-29c3e63bc509" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_2f801c26-0c5e-4d2f-a177-45ecc4ea94d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_25206aa2-98fc-4693-a89a-f4a8def612cc" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_2f801c26-0c5e-4d2f-a177-45ecc4ea94d3" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/LeasesSupplementalStatementofOperationsInformationDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#LeasesSupplementalStatementofOperationsInformationDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/LeasesSupplementalStatementofOperationsInformationDetails" xlink:type="extended" id="ia126586691de495799ca3a1a7c67cabc_LeasesSupplementalStatementofOperationsInformationDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionLineItems_c477c5eb-ed90-49e9-9783-64232bfd02d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseExpense_9a9690dd-f3cf-4183-a142-9bd9c9bf47ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_c477c5eb-ed90-49e9-9783-64232bfd02d1" xlink:to="loc_us-gaap_OperatingLeaseExpense_9a9690dd-f3cf-4183-a142-9bd9c9bf47ce" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeLeaseDescriptionTable_f0db3952-9e3f-4995-bf8a-c3e1db81da3e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LesseeLeaseDescriptionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LesseeLeaseDescriptionLineItems_c477c5eb-ed90-49e9-9783-64232bfd02d1" xlink:to="loc_us-gaap_LesseeLeaseDescriptionTable_f0db3952-9e3f-4995-bf8a-c3e1db81da3e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_3e8426dc-aa1e-427a-92a1-bcb0c8d42098" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LesseeLeaseDescriptionTable_f0db3952-9e3f-4995-bf8a-c3e1db81da3e" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_3e8426dc-aa1e-427a-92a1-bcb0c8d42098" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_3e8426dc-aa1e-427a-92a1-bcb0c8d42098_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_3e8426dc-aa1e-427a-92a1-bcb0c8d42098" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_3e8426dc-aa1e-427a-92a1-bcb0c8d42098_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_39e2cd2c-d5df-41cd-b766-71f714c1caa7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_3e8426dc-aa1e-427a-92a1-bcb0c8d42098" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_39e2cd2c-d5df-41cd-b766-71f714c1caa7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfSalesMember_7ff5a784-e248-4c28-8e47-b00b494e615b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CostOfSalesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_39e2cd2c-d5df-41cd-b766-71f714c1caa7" xlink:to="loc_us-gaap_CostOfSalesMember_7ff5a784-e248-4c28-8e47-b00b494e615b" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_e242fda3-bb91-4b49-934c-08cbf991df34" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_39e2cd2c-d5df-41cd-b766-71f714c1caa7" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_e242fda3-bb91-4b49-934c-08cbf991df34" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpenseMember_d9b9da44-fe1c-4a77-b090-a57fcd3d1b90" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SellingAndMarketingExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_39e2cd2c-d5df-41cd-b766-71f714c1caa7" xlink:to="loc_us-gaap_SellingAndMarketingExpenseMember_d9b9da44-fe1c-4a77-b090-a57fcd3d1b90" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_a1f3475b-9d93-49fb-8a95-5dfaa2a733ba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_39e2cd2c-d5df-41cd-b766-71f714c1caa7" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_a1f3475b-9d93-49fb-8a95-5dfaa2a733ba" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#CommitmentsandContingenciesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/CommitmentsandContingenciesNarrativeDetails" xlink:type="extended" id="i00d552977fb54f3795beebc0b09e2540_CommitmentsandContingenciesNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesLineItems_41a93c04-4e22-41d3-8f81-2dfed6236a56" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingenciesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_NumberOfPatentsAssertedForReexamination_3209ca7a-5811-4752-bfc1-5160ec819990" xlink:href="ango-20230531.xsd#ango_NumberOfPatentsAssertedForReexamination"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_41a93c04-4e22-41d3-8f81-2dfed6236a56" xlink:to="loc_ango_NumberOfPatentsAssertedForReexamination_3209ca7a-5811-4752-bfc1-5160ec819990" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_NumberOfPatentsUpheldOverPriorArtReferences_86fad2f3-a506-4bfc-8ccb-3ec47061f9a2" xlink:href="ango-20230531.xsd#ango_NumberOfPatentsUpheldOverPriorArtReferences"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_41a93c04-4e22-41d3-8f81-2dfed6236a56" xlink:to="loc_ango_NumberOfPatentsUpheldOverPriorArtReferences_86fad2f3-a506-4bfc-8ccb-3ec47061f9a2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingencyPatentsAllegedlyInfringedNumber_1b94d459-e972-4592-bc8e-4071e87adc22" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingencyPatentsAllegedlyInfringedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LossContingenciesLineItems_41a93c04-4e22-41d3-8f81-2dfed6236a56" xlink:to="loc_us-gaap_LossContingencyPatentsAllegedlyInfringedNumber_1b94d459-e972-4592-bc8e-4071e87adc22" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LossContingenciesTable_f595dff0-04c8-4b32-8575-7db11b31bb15" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LossContingenciesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_LossContingenciesLineItems_41a93c04-4e22-41d3-8f81-2dfed6236a56" xlink:to="loc_us-gaap_LossContingenciesTable_f595dff0-04c8-4b32-8575-7db11b31bb15" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseAxis_08cd1b82-bda7-41b6-8858-a3ddf638ddd3" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_LitigationCaseAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_LossContingenciesTable_f595dff0-04c8-4b32-8575-7db11b31bb15" xlink:to="loc_srt_LitigationCaseAxis_08cd1b82-bda7-41b6-8858-a3ddf638ddd3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_08cd1b82-bda7-41b6-8858-a3ddf638ddd3_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_LitigationCaseAxis_08cd1b82-bda7-41b6-8858-a3ddf638ddd3" xlink:to="loc_srt_LitigationCaseTypeDomain_08cd1b82-bda7-41b6-8858-a3ddf638ddd3_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_LitigationCaseTypeDomain_a46d144a-fb33-43fb-81ad-6f7be51cd211" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_LitigationCaseTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_LitigationCaseAxis_08cd1b82-bda7-41b6-8858-a3ddf638ddd3" xlink:to="loc_srt_LitigationCaseTypeDomain_a46d144a-fb33-43fb-81ad-6f7be51cd211" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_CrBardIncMember_a2f0ac88-a1d6-4753-9d85-9284fb6b4376" xlink:href="ango-20230531.xsd#ango_CrBardIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_a46d144a-fb33-43fb-81ad-6f7be51cd211" xlink:to="loc_ango_CrBardIncMember_a2f0ac88-a1d6-4753-9d85-9284fb6b4376" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_TheDelawareActionMember_3f1bee30-1084-42b9-bf17-777d0ba2eccb" xlink:href="ango-20230531.xsd#ango_TheDelawareActionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_LitigationCaseTypeDomain_a46d144a-fb33-43fb-81ad-6f7be51cd211" xlink:to="loc_ango_TheDelawareActionMember_3f1bee30-1084-42b9-bf17-777d0ba2eccb" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/SegmentsandGeographicInformationNarrativeDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#SegmentsandGeographicInformationNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/SegmentsandGeographicInformationNarrativeDetails" xlink:type="extended" id="iaf0bf1c4b6354409bb8cd77e289f898d_SegmentsandGeographicInformationNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_458b7576-7e16-47ed-8260-bd40fe96cf3e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_210f8b33-2fab-4e81-b94b-b7a36ebf3455" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_458b7576-7e16-47ed-8260-bd40fe96cf3e" xlink:to="loc_us-gaap_NumberOfOperatingSegments_210f8b33-2fab-4e81-b94b-b7a36ebf3455" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_47c195aa-fde7-48ee-abbb-5d51b3dced23" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_458b7576-7e16-47ed-8260-bd40fe96cf3e" xlink:to="loc_us-gaap_Assets_47c195aa-fde7-48ee-abbb-5d51b3dced23" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_68846c47-2233-4d2c-ba3d-00548ec59356" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_458b7576-7e16-47ed-8260-bd40fe96cf3e" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_68846c47-2233-4d2c-ba3d-00548ec59356" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_76e02ea2-ec7b-4739-93a1-356476f9c5ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_458b7576-7e16-47ed-8260-bd40fe96cf3e" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_76e02ea2-ec7b-4739-93a1-356476f9c5ce" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_9b672a7a-4557-4f64-ab9a-c5bdec143be2" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_76e02ea2-ec7b-4739-93a1-356476f9c5ce" xlink:to="loc_srt_StatementGeographicalAxis_9b672a7a-4557-4f64-ab9a-c5bdec143be2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_9b672a7a-4557-4f64-ab9a-c5bdec143be2_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_9b672a7a-4557-4f64-ab9a-c5bdec143be2" xlink:to="loc_srt_SegmentGeographicalDomain_9b672a7a-4557-4f64-ab9a-c5bdec143be2_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_33042117-e365-40cc-982b-7045fc94b560" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_9b672a7a-4557-4f64-ab9a-c5bdec143be2" xlink:to="loc_srt_SegmentGeographicalDomain_33042117-e365-40cc-982b-7045fc94b560" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonUsMember_94084c03-0921-448a-9e99-9d0396183524" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonUsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_33042117-e365-40cc-982b-7045fc94b560" xlink:to="loc_us-gaap_NonUsMember_94084c03-0921-448a-9e99-9d0396183524" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_48d7182c-bc5b-422c-a743-65ae948232ea" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_33042117-e365-40cc-982b-7045fc94b560" xlink:to="loc_country_US_48d7182c-bc5b-422c-a743-65ae948232ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_71b92898-d22e-4e86-971f-3807319dfd4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_76e02ea2-ec7b-4739-93a1-356476f9c5ce" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_71b92898-d22e-4e86-971f-3807319dfd4d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_71b92898-d22e-4e86-971f-3807319dfd4d_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_71b92898-d22e-4e86-971f-3807319dfd4d" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_71b92898-d22e-4e86-971f-3807319dfd4d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_1ed3ecf8-417a-4a94-a4f9-ecd74cc985d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_71b92898-d22e-4e86-971f-3807319dfd4d" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_1ed3ecf8-417a-4a94-a4f9-ecd74cc985d3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerMember_05b1ad24-7e9a-409a-8681-a0edd5763440" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_1ed3ecf8-417a-4a94-a4f9-ecd74cc985d3" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerMember_05b1ad24-7e9a-409a-8681-a0edd5763440" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetAssetsGeographicAreaMember_b8065ffe-68b6-4c34-8069-58e7ff068566" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetAssetsGeographicAreaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_1ed3ecf8-417a-4a94-a4f9-ecd74cc985d3" xlink:to="loc_us-gaap_NetAssetsGeographicAreaMember_b8065ffe-68b6-4c34-8069-58e7ff068566" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_80e047d6-c60f-42f9-a542-c9d0a248c1d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_76e02ea2-ec7b-4739-93a1-356476f9c5ce" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_80e047d6-c60f-42f9-a542-c9d0a248c1d0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_80e047d6-c60f-42f9-a542-c9d0a248c1d0_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_80e047d6-c60f-42f9-a542-c9d0a248c1d0" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_80e047d6-c60f-42f9-a542-c9d0a248c1d0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_62da4209-03ef-48e3-98f3-018fa411d946" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_80e047d6-c60f-42f9-a542-c9d0a248c1d0" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_62da4209-03ef-48e3-98f3-018fa411d946" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeographicConcentrationRiskMember_54c6b35d-0929-4f2c-bb58-888536f16d0f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeographicConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_62da4209-03ef-48e3-98f3-018fa411d946" xlink:to="loc_us-gaap_GeographicConcentrationRiskMember_54c6b35d-0929-4f2c-bb58-888536f16d0f" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/SegmentsandGeographicInformationSalesbyProductCategoryDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#SegmentsandGeographicInformationSalesbyProductCategoryDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/SegmentsandGeographicInformationSalesbyProductCategoryDetails" xlink:type="extended" id="ie86e286db3b047699187f6c93fc2e4f6_SegmentsandGeographicInformationSalesbyProductCategoryDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingInformationLineItems_b259ffc1-470c-4b3e-9c50-67f29c5aab68" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentReportingInformationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_0260c65f-470c-404e-ab9e-22013ea6bec5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_b259ffc1-470c-4b3e-9c50-67f29c5aab68" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_0260c65f-470c-404e-ab9e-22013ea6bec5" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_adc2286d-9e05-41c3-a59d-6e734357f389" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GrossProfit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_b259ffc1-470c-4b3e-9c50-67f29c5aab68" xlink:to="loc_us-gaap_GrossProfit_adc2286d-9e05-41c3-a59d-6e734357f389" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_GrossMarginPercentage_e70d0a4a-97c0-4a60-b5fa-d33427f45249" xlink:href="ango-20230531.xsd#ango_GrossMarginPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_b259ffc1-470c-4b3e-9c50-67f29c5aab68" xlink:to="loc_ango_GrossMarginPercentage_e70d0a4a-97c0-4a60-b5fa-d33427f45249" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_a5d930aa-7f00-44ba-91df-7a93133c9f8d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SegmentReportingInformationLineItems_b259ffc1-470c-4b3e-9c50-67f29c5aab68" xlink:to="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_a5d930aa-7f00-44ba-91df-7a93133c9f8d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_9afe7992-84ca-4c0a-b105-6080b1fab2a0" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfSegmentReportingInformationBySegmentTable_a5d930aa-7f00-44ba-91df-7a93133c9f8d" xlink:to="loc_srt_ProductOrServiceAxis_9afe7992-84ca-4c0a-b105-6080b1fab2a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_9afe7992-84ca-4c0a-b105-6080b1fab2a0_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_9afe7992-84ca-4c0a-b105-6080b1fab2a0" xlink:to="loc_srt_ProductsAndServicesDomain_9afe7992-84ca-4c0a-b105-6080b1fab2a0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_8f400a14-711c-4222-8b8f-40f063a3871e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_9afe7992-84ca-4c0a-b105-6080b1fab2a0" xlink:to="loc_srt_ProductsAndServicesDomain_8f400a14-711c-4222-8b8f-40f063a3871e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_MedTechMember_96543562-46aa-4347-a76b-72aac3737c86" xlink:href="ango-20230531.xsd#ango_MedTechMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_8f400a14-711c-4222-8b8f-40f063a3871e" xlink:to="loc_ango_MedTechMember_96543562-46aa-4347-a76b-72aac3737c86" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_MedDeviceMember_40a6a287-5d54-4c70-b7ab-2243be7621b2" xlink:href="ango-20230531.xsd#ango_MedDeviceMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_8f400a14-711c-4222-8b8f-40f063a3871e" xlink:to="loc_ango_MedDeviceMember_40a6a287-5d54-4c70-b7ab-2243be7621b2" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/SegmentsandGeographicInformationSaleforGeographicAreasDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#SegmentsandGeographicInformationSaleforGeographicAreasDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/SegmentsandGeographicInformationSaleforGeographicAreasDetails" xlink:type="extended" id="i10ae32f0fad243029b95af30ca2208d6_SegmentsandGeographicInformationSaleforGeographicAreasDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_04b6b395-2f84-4364-bc02-ba60386e8064" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_374fdd80-20df-43c2-a8e2-d38dfc990c10" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_04b6b395-2f84-4364-bc02-ba60386e8064" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_374fdd80-20df-43c2-a8e2-d38dfc990c10" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_513afdf4-33df-40d6-8c08-cb58a75c0039" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RevenuesFromExternalCustomersAndLongLivedAssetsLineItems_04b6b395-2f84-4364-bc02-ba60386e8064" xlink:to="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_513afdf4-33df-40d6-8c08-cb58a75c0039" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_af031897-0096-46c1-9411-7fe860e99680" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRevenuesFromExternalCustomersAndLongLivedAssetsTable_513afdf4-33df-40d6-8c08-cb58a75c0039" xlink:to="loc_srt_StatementGeographicalAxis_af031897-0096-46c1-9411-7fe860e99680" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_af031897-0096-46c1-9411-7fe860e99680_default" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_af031897-0096-46c1-9411-7fe860e99680" xlink:to="loc_srt_SegmentGeographicalDomain_af031897-0096-46c1-9411-7fe860e99680_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_3603ac44-b0be-43e5-a108-69660537527b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_af031897-0096-46c1-9411-7fe860e99680" xlink:to="loc_srt_SegmentGeographicalDomain_3603ac44-b0be-43e5-a108-69660537527b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_US_7a928337-78aa-4835-8fbb-8acebb345e82" xlink:href="https://xbrl.sec.gov/country/2022/country-2022.xsd#country_US"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_3603ac44-b0be-43e5-a108-69660537527b" xlink:to="loc_country_US_7a928337-78aa-4835-8fbb-8acebb345e82" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_InternationalMember_4b3c42dc-1422-4f1d-b4f1-fda76fb9b1d7" xlink:href="ango-20230531.xsd#ango_InternationalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_3603ac44-b0be-43e5-a108-69660537527b" xlink:to="loc_ango_InternationalMember_4b3c42dc-1422-4f1d-b4f1-fda76fb9b1d7" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/AcquisitionRestructuringandOtherItemsnetScheduleDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#AcquisitionRestructuringandOtherItemsnetScheduleDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/AcquisitionRestructuringandOtherItemsnetScheduleDetails" xlink:type="extended" id="ifda11dcfdb8a49efbeed76e1585804c8_AcquisitionRestructuringandOtherItemsnetScheduleDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_9d086507-b58f-410f-9ac6-bb2ee5cd35d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_AcquisitionRestructuringAndOtherItemsNet_7d80eb20-def8-426f-9533-6d09f1f4313d" xlink:href="ango-20230531.xsd#ango_AcquisitionRestructuringAndOtherItemsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_9d086507-b58f-410f-9ac6-bb2ee5cd35d5" xlink:to="loc_ango_AcquisitionRestructuringAndOtherItemsNet_7d80eb20-def8-426f-9533-6d09f1f4313d" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetImpairmentCharges_61da4949-401e-462f-9eb5-bcec07d9aac7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetImpairmentCharges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_9d086507-b58f-410f-9ac6-bb2ee5cd35d5" xlink:to="loc_us-gaap_AssetImpairmentCharges_61da4949-401e-462f-9eb5-bcec07d9aac7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForPreviousAcquisition_7623a46b-c52e-4f14-aae2-674b5ed06c66" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsForPreviousAcquisition"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_9d086507-b58f-410f-9ac6-bb2ee5cd35d5" xlink:to="loc_us-gaap_PaymentsForPreviousAcquisition_7623a46b-c52e-4f14-aae2-674b5ed06c66" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_ef4ada78-3af0-46dd-80ad-076f1a62f931" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_9d086507-b58f-410f-9ac6-bb2ee5cd35d5" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_ef4ada78-3af0-46dd-80ad-076f1a62f931" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_8610d4bc-518f-48d0-a9b4-83b51fd83aac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_ef4ada78-3af0-46dd-80ad-076f1a62f931" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_8610d4bc-518f-48d0-a9b4-83b51fd83aac" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_8610d4bc-518f-48d0-a9b4-83b51fd83aac_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_8610d4bc-518f-48d0-a9b4-83b51fd83aac" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_8610d4bc-518f-48d0-a9b4-83b51fd83aac_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_6d3d10c8-234d-4e39-aea6-771a4fc7a8fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_8610d4bc-518f-48d0-a9b4-83b51fd83aac" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_6d3d10c8-234d-4e39-aea6-771a4fc7a8fd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_LegalCostsMember_0d071c8c-efaa-4838-936f-76b8fc9d92f3" xlink:href="ango-20230531.xsd#ango_LegalCostsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_6d3d10c8-234d-4e39-aea6-771a4fc7a8fd" xlink:to="loc_ango_LegalCostsMember_0d071c8c-efaa-4838-936f-76b8fc9d92f3" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_MergersandAcquisitionsMember_9100324f-78d9-46bb-9a62-d02b8000da78" xlink:href="ango-20230531.xsd#ango_MergersandAcquisitionsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_6d3d10c8-234d-4e39-aea6-771a4fc7a8fd" xlink:to="loc_ango_MergersandAcquisitionsMember_9100324f-78d9-46bb-9a62-d02b8000da78" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_TransitionServiceAgreementMember_27925e8d-7da1-4314-8d35-e260c16dd953" xlink:href="ango-20230531.xsd#ango_TransitionServiceAgreementMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_6d3d10c8-234d-4e39-aea6-771a4fc7a8fd" xlink:to="loc_ango_TransitionServiceAgreementMember_27925e8d-7da1-4314-8d35-e260c16dd953" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_DivestitureMember_c6013b9d-3f89-43aa-9a38-2399354efd9b" xlink:href="ango-20230531.xsd#ango_DivestitureMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_6d3d10c8-234d-4e39-aea6-771a4fc7a8fd" xlink:to="loc_ango_DivestitureMember_c6013b9d-3f89-43aa-9a38-2399354efd9b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_IntangibleImpairmentMember_01a0df22-8b2a-45d9-a140-e5dbdc5f4373" xlink:href="ango-20230531.xsd#ango_IntangibleImpairmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_6d3d10c8-234d-4e39-aea6-771a4fc7a8fd" xlink:to="loc_ango_IntangibleImpairmentMember_01a0df22-8b2a-45d9-a140-e5dbdc5f4373" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_IsraeliInnovationAuthorityPrepaymentMember_dbb5fbd4-2b0d-4d9d-9f45-eea7593c9c56" xlink:href="ango-20230531.xsd#ango_IsraeliInnovationAuthorityPrepaymentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_6d3d10c8-234d-4e39-aea6-771a4fc7a8fd" xlink:to="loc_ango_IsraeliInnovationAuthorityPrepaymentMember_dbb5fbd4-2b0d-4d9d-9f45-eea7593c9c56" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_ManufacturingRelocationMember_b9322a79-c397-4126-8aa1-b6efb92615c1" xlink:href="ango-20230531.xsd#ango_ManufacturingRelocationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_6d3d10c8-234d-4e39-aea6-771a4fc7a8fd" xlink:to="loc_ango_ManufacturingRelocationMember_b9322a79-c397-4126-8aa1-b6efb92615c1" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherRestructuringMember_2ba4b876-bbff-4c9f-b229-a0b7bb9349bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherRestructuringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_6d3d10c8-234d-4e39-aea6-771a4fc7a8fd" xlink:to="loc_us-gaap_OtherRestructuringMember_2ba4b876-bbff-4c9f-b229-a0b7bb9349bc" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_0586b46e-0b7d-4c28-908e-15565340b555" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_ef4ada78-3af0-46dd-80ad-076f1a62f931" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_0586b46e-0b7d-4c28-908e-15565340b555" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0586b46e-0b7d-4c28-908e-15565340b555_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_0586b46e-0b7d-4c28-908e-15565340b555" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0586b46e-0b7d-4c28-908e-15565340b555_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_94b99e46-5bd7-4be3-bcdb-6614caeb1015" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_0586b46e-0b7d-4c28-908e-15565340b555" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_94b99e46-5bd7-4be3-bcdb-6614caeb1015" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_RadiaDyneMember_fba146e0-ff5a-47c4-86bf-1e17ae711314" xlink:href="ango-20230531.xsd#ango_RadiaDyneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_94b99e46-5bd7-4be3-bcdb-6614caeb1015" xlink:to="loc_ango_RadiaDyneMember_fba146e0-ff5a-47c4-86bf-1e17ae711314" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_7ada71f5-adcb-4e0b-88fc-6123e2b9d88c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_ef4ada78-3af0-46dd-80ad-076f1a62f931" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_7ada71f5-adcb-4e0b-88fc-6123e2b9d88c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_7ada71f5-adcb-4e0b-88fc-6123e2b9d88c_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_7ada71f5-adcb-4e0b-88fc-6123e2b9d88c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_7ada71f5-adcb-4e0b-88fc-6123e2b9d88c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_9103920f-9dce-400c-bcec-23b6fe7e0764" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_7ada71f5-adcb-4e0b-88fc-6123e2b9d88c" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_9103920f-9dce-400c-bcec-23b6fe7e0764" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_OarTracTrademarkMember_2166b13c-17ce-4da5-8045-51a0126d280a" xlink:href="ango-20230531.xsd#ango_OarTracTrademarkMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_9103920f-9dce-400c-bcec-23b6fe7e0764" xlink:to="loc_ango_OarTracTrademarkMember_2166b13c-17ce-4da5-8045-51a0126d280a" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/AcquisitionRestructuringandOtherItemsnetNarrativeDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#AcquisitionRestructuringandOtherItemsnetNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/AcquisitionRestructuringandOtherItemsnetNarrativeDetails" xlink:type="extended" id="id5dbbbaa95044db2b1d26b4cb598e52a_AcquisitionRestructuringandOtherItemsnetNarrativeDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveLineItems_6bf3550e-b33e-40da-8f72-40e6c33fd451" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringCostAndReserveLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_AcquisitionRestructuringAndOtherItemsNet_79fd3610-2091-4d50-a138-d2a3dce86860" xlink:href="ango-20230531.xsd#ango_AcquisitionRestructuringAndOtherItemsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_6bf3550e-b33e-40da-8f72-40e6c33fd451" xlink:to="loc_ango_AcquisitionRestructuringAndOtherItemsNet_79fd3610-2091-4d50-a138-d2a3dce86860" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_b97a6d19-58ed-4a81-bcc1-bb1235dd0de7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRestructuringAndRelatedCostsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_RestructuringCostAndReserveLineItems_6bf3550e-b33e-40da-8f72-40e6c33fd451" xlink:to="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_b97a6d19-58ed-4a81-bcc1-bb1235dd0de7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCostAndReserveAxis_25c4f202-1cbd-4a34-8470-b8d68eb1cf40" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestructuringCostAndReserveAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfRestructuringAndRelatedCostsTable_b97a6d19-58ed-4a81-bcc1-bb1235dd0de7" xlink:to="loc_us-gaap_RestructuringCostAndReserveAxis_25c4f202-1cbd-4a34-8470-b8d68eb1cf40" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_25c4f202-1cbd-4a34-8470-b8d68eb1cf40_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_25c4f202-1cbd-4a34-8470-b8d68eb1cf40" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_25c4f202-1cbd-4a34-8470-b8d68eb1cf40_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfRestructuringDomain_80390d57-b012-4a6b-9f83-055e15c475c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfRestructuringDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RestructuringCostAndReserveAxis_25c4f202-1cbd-4a34-8470-b8d68eb1cf40" xlink:to="loc_us-gaap_TypeOfRestructuringDomain_80390d57-b012-4a6b-9f83-055e15c475c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_SettlementExpenseMember_3475ab08-21f2-45ff-9ccb-5f2ba5e167ac" xlink:href="ango-20230531.xsd#ango_SettlementExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfRestructuringDomain_80390d57-b012-4a6b-9f83-055e15c475c8" xlink:to="loc_ango_SettlementExpenseMember_3475ab08-21f2-45ff-9ccb-5f2ba5e167ac" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/AccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#AccumulatedOtherComprehensiveIncomeLossDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/AccumulatedOtherComprehensiveIncomeLossDetails" xlink:type="extended" id="ie36937e5476e49e0b81ccadf75722afa_AccumulatedOtherComprehensiveIncomeLossDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_885ac517-3a3c-4c00-be6a-757d8904eee8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_f592769b-cde7-473e-b71c-8c36af4c74ac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AOCIAttributableToParentNetOfTaxRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassOfStockLineItems_885ac517-3a3c-4c00-be6a-757d8904eee8" xlink:to="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_f592769b-cde7-473e-b71c-8c36af4c74ac" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_d0dd9336-27a9-43b3-90a3-a3377c59220e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_f592769b-cde7-473e-b71c-8c36af4c74ac" xlink:to="loc_us-gaap_StockholdersEquity_d0dd9336-27a9-43b3-90a3-a3377c59220e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OciBeforeReclassificationsBeforeTaxAttributableToParent_ad20533c-4295-464e-925b-3ee540bdf046" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OciBeforeReclassificationsBeforeTaxAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_f592769b-cde7-473e-b71c-8c36af4c74ac" xlink:to="loc_us-gaap_OciBeforeReclassificationsBeforeTaxAttributableToParent_ad20533c-4295-464e-925b-3ee540bdf046" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_d803fe27-8985-48f0-b008-0a44563df280" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AOCIAttributableToParentNetOfTaxRollForward_f592769b-cde7-473e-b71c-8c36af4c74ac" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_d803fe27-8985-48f0-b008-0a44563df280" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_19ac1f4a-08fa-4c65-ad77-8d3f9a72736f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_842197dc-47d3-440a-a9ba-2a1c0464f45d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ClassOfStockLineItems_885ac517-3a3c-4c00-be6a-757d8904eee8" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_842197dc-47d3-440a-a9ba-2a1c0464f45d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_8e98c979-ca63-4871-be03-bfed57bc7efe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_842197dc-47d3-440a-a9ba-2a1c0464f45d" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_8e98c979-ca63-4871-be03-bfed57bc7efe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_8e98c979-ca63-4871-be03-bfed57bc7efe_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_8e98c979-ca63-4871-be03-bfed57bc7efe" xlink:to="loc_us-gaap_EquityComponentDomain_8e98c979-ca63-4871-be03-bfed57bc7efe_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_dc4bbc0e-d51b-4084-b032-9283ef59977d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_8e98c979-ca63-4871-be03-bfed57bc7efe" xlink:to="loc_us-gaap_EquityComponentDomain_dc4bbc0e-d51b-4084-b032-9283ef59977d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedTranslationAdjustmentMember_9d22b8f5-6f0c-4dba-aff2-707f2c7cbabc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedTranslationAdjustmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_dc4bbc0e-d51b-4084-b032-9283ef59977d" xlink:to="loc_us-gaap_AccumulatedTranslationAdjustmentMember_9d22b8f5-6f0c-4dba-aff2-707f2c7cbabc" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/SubsequentEventsDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#SubsequentEventsDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/SubsequentEventsDetails" xlink:type="extended" id="i001b64a59db2432299b9d76db0eaa6b7_SubsequentEventsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventLineItems_03577fc2-b9b8-4ed1-9405-bb49bf7ea5ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfOtherAssets1_7205e9cb-a921-420f-bfca-b557b837496c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleOfOtherAssets1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventLineItems_03577fc2-b9b8-4ed1-9405-bb49bf7ea5ee" xlink:to="loc_us-gaap_ProceedsFromSaleOfOtherAssets1_7205e9cb-a921-420f-bfca-b557b837496c" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTable_f53d3407-d486-4794-81ef-455d4a69a2ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_SubsequentEventLineItems_03577fc2-b9b8-4ed1-9405-bb49bf7ea5ee" xlink:to="loc_us-gaap_SubsequentEventTable_f53d3407-d486-4794-81ef-455d4a69a2ed" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_4f60936f-ef9c-4319-95f1-d71cd79abe50" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_SubsequentEventTable_f53d3407-d486-4794-81ef-455d4a69a2ed" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_4f60936f-ef9c-4319-95f1-d71cd79abe50" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_4f60936f-ef9c-4319-95f1-d71cd79abe50_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_4f60936f-ef9c-4319-95f1-d71cd79abe50" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_4f60936f-ef9c-4319-95f1-d71cd79abe50_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_b20dbe7c-de5b-41a4-b5f4-2d35daadb9d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_4f60936f-ef9c-4319-95f1-d71cd79abe50" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_b20dbe7c-de5b-41a4-b5f4-2d35daadb9d3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_7e2d046e-0566-4797-88b1-9159a3422e63" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_b20dbe7c-de5b-41a4-b5f4-2d35daadb9d3" xlink:to="loc_us-gaap_SubsequentEventMember_7e2d046e-0566-4797-88b1-9159a3422e63" xlink:type="arc" order="0"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.angiodynamics.com/role/ValuationandQualifyingAccountsDetails" xlink:type="simple" xlink:href="ango-20230531.xsd#ValuationandQualifyingAccountsDetails"/>
  <link:definitionLink xlink:role="http://www.angiodynamics.com/role/ValuationandQualifyingAccountsDetails" xlink:type="extended" id="icafa3a97fd1b4cb8909b348e5aba1a8b_ValuationandQualifyingAccountsDetails">
    <link:loc xlink:type="locator" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_314ee58c-bea9-429e-aa4e-0bed9cabd443" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ValuationAndQualifyingAccountsDisclosureLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_9f8b3ef4-1e2b-4320-8785-87ffa5982b94" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MovementInValuationAllowancesAndReservesRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_314ee58c-bea9-429e-aa4e-0bed9cabd443" xlink:to="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_9f8b3ef4-1e2b-4320-8785-87ffa5982b94" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_d23548b5-5acf-437e-84d3-1e223d1f8f89" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesBalance"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_9f8b3ef4-1e2b-4320-8785-87ffa5982b94" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesBalance_d23548b5-5acf-437e-84d3-1e223d1f8f89" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_ebdbfca0-ec95-4bb0-bf24-bdd790252996" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_9f8b3ef4-1e2b-4320-8785-87ffa5982b94" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesChargedToCostAndExpense_ebdbfca0-ec95-4bb0-bf24-bdd790252996" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDeductions_0758cb37-6cad-4f1a-8201-d959a81aaa57" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesDeductions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MovementInValuationAllowancesAndReservesRollForward_9f8b3ef4-1e2b-4320-8785-87ffa5982b94" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDeductions_0758cb37-6cad-4f1a-8201-d959a81aaa57" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesBalance_b1fc9205-f9dd-4ebf-8acb-b4ef44bfe7ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesBalance"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_d22fdf6a-01fc-4d9b-9386-a0ab2f4b7e81" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ValuationAndQualifyingAccountsDisclosureTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureLineItems_314ee58c-bea9-429e-aa4e-0bed9cabd443" xlink:to="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_d22fdf6a-01fc-4d9b-9386-a0ab2f4b7e81" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_ac8f622e-6095-472b-b7cf-887139ad6341" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_srt_ValuationAndQualifyingAccountsDisclosureTable_d22fdf6a-01fc-4d9b-9386-a0ab2f4b7e81" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_ac8f622e-6095-472b-b7cf-887139ad6341" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_ac8f622e-6095-472b-b7cf-887139ad6341_default" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_ac8f622e-6095-472b-b7cf-887139ad6341" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_ac8f622e-6095-472b-b7cf-887139ad6341_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowancesAndReservesDomain_1838c7a0-82cf-4763-b727-a9a551490296" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowancesAndReservesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesTypeAxis_ac8f622e-6095-472b-b7cf-887139ad6341" xlink:to="loc_us-gaap_ValuationAllowancesAndReservesDomain_1838c7a0-82cf-4763-b727-a9a551490296" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember_55ab5aa6-940f-4b54-bdb9-114629103e24" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_1838c7a0-82cf-4763-b727-a9a551490296" xlink:to="loc_us-gaap_ValuationAllowanceOfDeferredTaxAssetsMember_55ab5aa6-940f-4b54-bdb9-114629103e24" xlink:type="arc" order="0"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_AllowanceForSalesReturnsAndDoubtfulAccountsMember_2e9026f4-f604-4e18-9605-bedad285e260" xlink:href="ango-20230531.xsd#ango_AllowanceForSalesReturnsAndDoubtfulAccountsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ValuationAllowancesAndReservesDomain_1838c7a0-82cf-4763-b727-a9a551490296" xlink:to="loc_ango_AllowanceForSalesReturnsAndDoubtfulAccountsMember_2e9026f4-f604-4e18-9605-bedad285e260" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="simple" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-roles-2022.xsd#eedm"/>
  <link:definitionLink xlink:role="http://fasb.org/us-gaap/role/eedm/ExtensibleEnumerationLists" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_ango_AcquisitionRestructuringAndOtherItemsNet_d9a7993a-ec74-4a12-b732-940f39ba2f9f" xlink:href="ango-20230531.xsd#ango_AcquisitionRestructuringAndOtherItemsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementAbstract" xlink:to="loc_ango_AcquisitionRestructuringAndOtherItemsNet_d9a7993a-ec74-4a12-b732-940f39ba2f9f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AssetsAbstract" xlink:to="loc_us-gaap_OtherAssetsNoncurrent" xlink:type="arc" order="1"/>
  </link:definitionLink>
</link:linkbase>
